503073-45-8

Upstream product

• 72418-40-7 3-phenylisoxazole-5-carbaldehyde 
• 75-36-5 acetyl chloride 
• 337355-83-6 2-[hydroxy-(3-phenyl-isoxazol-5-yl)-methyl]-acrylic acid methyl ester 

Downstream Products

• 713137-94-1 2-(3-phenyl-isoxazol-5-ylmethyl)-acrylic acid methyl ester 
• 884537-22-8 2-[2-acetyl-3-oxo-1-(3-phenylisoxazol-5-yl)butyl]acrylic acid methyl ester 
• 1189021-47-3 methyl 5-[acetyloxy-(3-phenylisoxazol-5-yl)methyl]-3-(2-nitrophenyl)-4,5-dihydroisoxazole-5-carboxylate 

Relevant academic research and scientific papers

Convenient synthesis of substituted α-methylene-δ- valerolactones in aqueous medium using Baylis-Hillman chemistry

A mild and convenient synthesis of substituted α-methylene-δ- valerolactones was achieved by SN2 nucleophilic substitution of the acetates of Baylis-Hillman adducts with acetyl acetone followed by one-pot saponification of the ester, reduction

Baylis-Hillman reaction assisted parallel synthesis of 3,5-disubstituted isoxazoles and their in vivo bioevaluation as antithrombotic agents

The solution-phase parallel synthesis involving reactions of Baylis-Hillman products of 3-substituted-5-isoxazolecarbaldehydes with nucleophiles and their in vivo antithrombotic evaluations are described along with the results of in vitro platelet aggregation inhibition assay of a few compounds. Results of the detailed evaluation of one of the compounds as an inhibitor of platelet aggregation are also presented.

Studies on the catalytic hydrogenation of Baylis-Hillman derivatives of substituted isoxazolecarbaldehydes. Unusual retention of isoxazole ring during Pd-C-promoted hydrogenation of Baylis-Hillman adducts

Results of the catalytic hydrogenation of Baylis-Hillman adducts obtained from substituted 3-, 4- and 5-isoxazolecarbox-aldehydes and their corresponding acetates in the presence of Raney-Ni and Pd-C are presented. The hydrogenation of Baylis-Hillman addu

Isoxazole-based derivatives from Baylis-Hillman chemistry: Assessment of preliminary hypolipidemic activity

The synthesis of isoxazole-based derivatives utilizing Baylis-Hillman chemistry and results of their preliminary bioevaluation as hypolipidemic agents in triton model are described.