337535-27-0Relevant academic research and scientific papers
Visible-Light-Promoted, Catalyst-Free Gomberg-Bachmann Reaction: Synthesis of Biaryls
Lee, Juyoung,Hong, Boseok,Lee, Anna
, p. 9297 - 9306 (2019/08/12)
Biaryls were synthesized via a novel visible-light-promoted Gomberg-Bachmann reaction that does not require a photosensitizer or any metal reagents. The formation of an electron donor-acceptor complex between aryl diazonium salts and pyridine allows, under visible-light irradiation, the synthesis of biaryls in moderate-to-high yields.
Novel estrone mimetics with high 17β-HSD1 inhibitory activity
Oster, Alexander,Klein, Tobias,Werth, Ruth,Kruchten, Patricia,Bey, Emmanuel,Negri, Matthias,Marchais-Oberwinkler, Sandrine,Frotscher, Martin,Hartmann, Rolf W.
scheme or table, p. 3494 - 3505 (2010/10/19)
17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) catalyzes the reduction of estrone into estradiol, which is the most potent estrogen in humans. Lowering intracellular estradiol concentration by inhibition of this enzyme is a promising new option for th
Controlled monoarylation of dibromoarenes in water with a polymeric palladium catalyst
Uozumi, Yasuhiro,Kikuchi, Makoto
, p. 1775 - 1778 (2007/10/03)
A highly selective monoarylation of dibromoarenes was performed via the Suzuki-Miyaura cross-coupling with arylboronic acids with an amphiphilic polystyrene-poly(ethylene glycol) (PS-PEG) resin-supported phosphine-palladium complex in water under heteroge
1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use thereof
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, (2008/06/13)
To provide a composition having a steroid C17,20-lyase inhibitory activity and useful as an agent for the prophylaxis or treatment of prostatism and tumors such as breast cancer. A compound represented by the formula: wherein R is a hydrogen atom or a protecting group, R1is a lower alkyl group or a cyclic hydrocarbon group, R2is an aromatic hydrocarbon group optionally having substituents or an aromatic heterocyclic group optionally having substituents, R3is a hydrocarbon group optionally having substituents, a hydroxyl group optionally having substituents, a thiol group optionally having substituents, an amino group optionally having substituents, an acyl group or a halogen atom, and n is an integer of 0 to 4, and a salt thereof have a steroid C17,20-lyase inhibitory activity, and are useful as an agent for the pophylaxis or treatment of prostatism and tumors such as beast cancer and the like.
