3376-38-3Relevant academic research and scientific papers
Iridium-Catalyzed Unreactive C(sp3)-H Amination with 2,2,2-Trichloroethoxycarbonyl Azide
Zhang, Tao,Hu, Xuejiao,Dong, Xunqing,Li, Guigen,Lu, Hongjian
supporting information, p. 6260 - 6264 (2018/10/02)
An additive-assisted iridium-catalyzed directed C(sp3)-H amination with 2,2,2-trichloroethoxycarbonyl azide as an amino source is reported. Both carboxylate anions and the corresponding cations in the additives are crucial to achieve satisfactory efficiency. Sodium acetate or n-pentanoic acid can promote the amination of various primary C(sp3)-H bonds adjacent to secondary, tertiary, and quaternary carbons in ketoximes or N-aromatic heterocycles, respectively, providing a practical route to versatile β-amino ketoxime and N-heteroaryl ethanamine derivatives. The amination products can be treated as isocyanate analogues and can be converted to other useful amino functionalities. An iridacyclic compound was isolated and identified as a plausible intermediate.
Synthesis of 1,2-amino alcohols via catalytic C-H amidation of sp3 methyl C-H bonds
Kang, Taek,Kim, Heejeong,Kim, Jeung Gon,Chang, Sukbok
, p. 12073 - 12075 (2014/12/11)
Herein a new synthetic route to 1,2-amino alcohols is presented by using C-H amidation of sp3 methyl C-H bonds as a key step. Readily available alcohols were employed as starting materials after converting them to removable ketoxime chelating g
