20940-07-2

Upstream product

• 20940-09-4 2-(2-nitro-phenylsulfanyl)-1-phenyl-ethanone 
• 137-07-5 2-amino-benzenethiol 
• 70-11-1 α-bromoacetophenone 
• 24290-25-3 4-(2-nitro-phenylsulfanyl)-3-phenyl-2H-isoxazol-5-one 
• 1155-00-6 bis(2-nitrophenyl)disulfide 
• 24290-17-3 2-(2-nitro-phenylsulfanyl)-3-oxo-3-phenyl-propionic acid ethyl ester 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 7669-54-7 2-nitrobenzenesulfenyl chloride 
• 52380-58-2 sodium 2-aminothiophenol 
• 98-86-2 acetophenone 
• 4875-10-9 o-nitrothiophenol 
• 2564-83-2 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical 
• 1141-88-4 2-Aminophenyl disulfide 

Downstream Products

• 20940-10-7 2-(3-phenyl-2H-1,4-benzthiazin-2-yl)-3-phenyl-2H-1,4-benzothiazine 
• 100-41-4 ethylbenzene 
• 7783-06-4 hydrogen sulfide 
• 62-53-3 aniline 
• 932406-01-4 1,1-dichloro-1a-phenyl-1a,2-dihydro-1H-azireno[2,1-c][1,4]-benzothiazine 
• 33795-58-3 3-phenyl-2H-benzo[b][1,4]thiazin-2-one 
• 1429933-81-2 (S)-3-phenyl-3,4-dihydro-2H-benzo[b][1,4]thiazin-2-one 
• 23416-79-7 (E)-Δ^2,2'-bi(3-phenyl-2H-1,4-benzothiazin-2-yl) 
• 1429933-88-9 (S)-3-phenyl-3,4-dihydro-2H-benzo[b][1,4]thiazine 
• 932406-08-1 3,4-dichloro-3-phenyl-2,3-dihydro-1,5-benzothiazepine 

Relevant academic research and scientific papers

Bioinspired Heterocyclic Partnership in a Cyanine-Type Acidichromic Chromophore

A new red hair-inspired 1,4-benzothiazine-based scaffold is disclosed herein, built upon a modular D-π-A architecture via condensation of the easily accessible 3-phenyl-2H-1,4-benzothiazine with indole-3-carboxaldehyde. The compound was obtained in around

Umpolung Strategy with 2-Aminothiophenols: Access to 2-Arylbenzothiazine Derivatives from Alkyl Aryl Ketones

Strong Br?nsted acids were found to catalyze the oxidative condensation of 2-aminothiophenols with aryl alkyl ketones in DMSO to provide a wide range of complex 2-arylbenzothiazines. With acetophenones, dimeric 2-arylbenzothiazines were formed. On the other hand, the reaction with propiophenones resulted in 2:1 adducts whereas 1:1 adducts were produced with isobutyrophenones, benzoylacetonitrile and ethyl benzoylacetate. (Figure presented.).

AIBN-Promoted Synthesis of Bibenzo[ b][1,4]thiazines by the Condensation of 2,2′-Dithiodianiline with Methyl Aryl Ketones

A series of bibenzo[b][1,4]thiazines with various functional groups has been synthesized by a free-radical condensation reaction. Bibenzo[b][1,4]thiazines were obtained in moderate to good yield (up to 85%) through a one-step reaction of readily available 2,2′-dithiodianiline and methyl aryl ketones with AIBN as radical initiator in HOAc. Bibenzo[b][1,4]thiazines exhibit diversiform solid-state packing.

Radical Route to 1,4-Benzothiazine Derivatives from 2-Aminobenzenethiols and Ketones under Transition-Metal-Free Conditions

Transition-metal-free radical access to 1,4-benzothiazine derivatives from o-aminobenzenethiols is disclosed. This procedure is available for various ketones including α,β-unsaturated, cyclic, linear, and fluoroalkyl ketones to generate a number of 1,4-benzothiazines, which exist in numerous bioactive and natural molecules, rendering this protocol attractive to both synthetic and medicinal chemistry.

Bioglycerol-based sulfonic acid-functionalized carbon catalyst as an efficient and reusable catalyst for one-pot synthesis of 3- substituted-2 h -1,4-benzothiazines

A simple and efficient synthetic protocol has been developed for the synthesis of 3-substituted-2H-1,4-benzothiazines by using bioglycerol-based sulfonic acid-functionalized carbon catalyst, devoid of corrosive acidic and basic reagents. The developed met

Red-hair-inspired chromogenic system based on a proton-switched dehydrogenative free-radical coupling

In the presence of micromolar peroxides or biometals (Fe(III), Cu(II), V(V) salts), and following a strong acid input, the stable 3-phenyl-2H-1,4- benzothiazine is efficiently converted to a green-blue Δ 2,2′-bi(2H-1,4-benzothiazine) chromophor

[Ir(P-OP)]-catalyzed asymmetric hydrogenation of diversely substituted C=N-containing heterocycles

Iridium(I) complexes of enantiomerically pure phosphine-phosphite ligands ([Ir(Cl)(cod)(P - OP)]) efficiently catalyze the enantioselective hydrogenation of diverse C=N-containing heterocyclic compounds (benzoxazines, benzoxazinones, benzothiazinones, and quinoxalinones; 25 examples, up to 99% ee). A substrate-to-catalyst ratio as high as 2000:1 was reached.

Practical and efficient synthesis of 3-aryl-2H-benzo[1,4]thiazine derivatives catalyzed by KHSO4

KHSO4 efficiently catalyzes the condensation of o-aminothiophenols and 2-bromo-1-aryl-ethanones to yield 3-aryl-2H-benzo[1,4] thiazines in good yields.

From phenothiazine to 3-phenyl-1,4-benzothiazine derivatives as inhibitors of the Staphylococcus aureus NorA multidrug efflux pump

Overexpression of efflux pumps is an important mechanism by which bacteria evade effects of substrate antimicrobial agents and inhibition of such pumps is a promising strategy to circumvent this resistance mechanism. NorA is a Staphylococcus aureus multid

Conversion of bis(o-nitrophenyl)disulfides to heterocycles containing sulfur and nitrogen by the action of samarium diiodide

Treatment of bis(o-nitrophenyl)disulfides 1 with SmI2 led to simultaneous reduction of nitro groups and reductive cleavage of S-S bonds as well as the formation of the active intermediates 2. The intermediates 2 reacted smoothly with aldehydes