337971-05-8

Basic information

• Product Name: (R)-(Z)-2-[6-(1-hydroxy-1-methylethyl)tetrahydropyran-3-ylidene]ethyl benzoate
• Synonyms: (R)-(Z)-2-[6-(1-hydroxy-1-methylethyl)tetrahydropyran-3-ylidene]ethyl benzoate
• CAS NO: 337971-05-8
• Molecular Weight: 290.359
• Mol File: 337971-05-8.mol

Chemical Properties

• CAS DataBase Reference: (R)-(Z)-2-[6-(1-hydroxy-1-methylethyl)tetrahydropyran-3-ylidene]ethyl benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(Z)-2-[6-(1-hydroxy-1-methylethyl)tetrahydropyran-3-ylidene]ethyl benzoate(337971-05-8)
• EPA Substance Registry System: (R)-(Z)-2-[6-(1-hydroxy-1-methylethyl)tetrahydropyran-3-ylidene]ethyl benzoate(337971-05-8)

Safety Data

• Hazardous Substances Data: 337971-05-8(Hazardous Substances Data)

Upstream product

• 130648-03-2 (R)-2-methyl-6-methyleneoct-7-ene-2,3-diol 
• 130648-02-1 2-hydroxy-2-methyl-6-methyleneoct-7-en-3-one 
• 100664-21-9 (+/-)-2-methyl-6-methylene-7-octene-2,3-diol 
• 123-35-3 7-methyl-3-methene-1,6-octadiene 
• 29414-55-9 6,7-epoxymyrcene 
• 337971-46-7 C₂₅H₃₀O₈S 
• 337970-98-6 4-[2-((R)-2,2,5,5-Tetramethyl-[1,3]dioxolan-4-yl)-ethyl]-3,6-dihydro-[1,2]dioxine 
• 209474-15-7 (R)-(Z)-2-[2-(2,2,5,5-tetramethyl[1,3]dioxolan-4-yl)ethyl]but-2-ene-1,4-diol 
• 98-88-4 benzoyl chloride 
• 209474-16-8 (R)-(Z)-2-[5-(2-hydroxyethylidene)tetrahydropyran-2-yl]propan-2-ol 
• 337970-96-4 (R)-2,2,4,4-tetramethyl-5-(3-methylenepent-4-enyl)[1,3]dioxolane 
• 337971-01-4 (R)-(Z)-2-[2-(2,2,5,5-tetramethyl[1,3]dioxolan-4-yl)ethyl]but-2-ene-1,4-diol bisbenzoate 
• 337971-02-5 (R)-(Z)-2-(3,4-dihydroxy-4-methylpentyl)but-2-ene-1,4-diol bisbenzoate 

Downstream Products

• 209474-17-9 Benzoic acid 2-[(R)-6-(2-methyl-oxiranyl)-dihydro-pyran-(3Z)-ylidene]-ethyl ester 
• 337971-11-6 (2R,2'RS)-(5Z)-5-[2''-(4'''-methoxybenzyloxy)ethylidene]-2-(2'-methyloxiranyl)tetrahydropyran 
• 209474-18-0 (R)-(5'Z)-2-{5'-[2''-(4'''-methoxybenzyloxy)ethylidene]tetrahydropyran-2'-yl}prop-2-en-1-ol 
• 337971-14-9 (R)-(5'Z)-triisopropyl{2-[5'-[2''-(4'''-methoxybenzyloxy)ethylidene]tetrahydropyran-2'-yl]allyloxy}silane 
• 215958-94-4 Triisopropyl-(2-{(R)-5-[(4E,8E,12E)-4,9,13,17-tetramethyl-3-phenylsulfanyl-octadeca-4,8,12,16-tetraen-(Z)-ylidene]-tetrahydro-pyran-2-yl}-allyloxy)-silane 
• 337971-37-6 (2-{(R)-5-[(E)-5,9-Dimethyl-3-phenylsulfanyl-deca-4,8-dien-(Z)-ylidene]-tetrahydro-pyran-2-yl}-allyloxy)-triisopropyl-silane 
• 337971-20-7 Triisopropyl-(2-{(R)-5-[(4E,8E,12E)-5,9,13,17-tetramethyl-3-phenylsulfanyl-octadeca-4,8,12,16-tetraen-(Z)-ylidene]-tetrahydro-pyran-2-yl}-allyloxy)-silane 
• 337971-07-0 (R)-(Z)-2-(6-isopropenyltetrahydropyran-3-ylidene)ethyl benzoate 

Relevant articles and documents

Enantioselective total synthesis and absolute stereostructure of hippospongic acid A

A compound having the structure proposed for hippospongic acid A, a triterpene that specifically inhibits gastrulation of starfish embryos, was synthesized enantioselectively. The synthetic compound was not identical to the natural product. Comparison of the NMR spectra of the natural and synthetic compounds led us to propose an alternative structure, which was confirmed by enantioselective synthesis. The present synthesis established that the natural product has the (R)-configuration.

Enantioselective synthesis of reported hippospongic acid A

Total synthesis of hippospongic acid A, an inhibitor of gastrulation of starfish embryos, has been studied. A compound having the structure assigned to hippospongic acid A was synthesized enantioselectively. The spectral data of the synthetic compound were slightly different from those of the natural product and an alternative structure was proposed for the natural product.