33832-15-4Relevant academic research and scientific papers
Synthesis of symmetric dicyclohexanocucurbit[6]uril and its interaction with glycine
Jin, Yan-Mei,Ma, Pei-Hua,Meng, Ye
, (2021/09/02)
In this study, cyclohexanol was used as the raw material to replace cyclohexanone during the synthesis of symmetric dicyclohexanocucurbit[6]uril (CyH2Q[6]), which successfully avoided the use of selenium dioxide and greatly improved the yield of cyclohexyl-substituted glycoluril as the intermediate product (96%). In addition, using CyH2Q[6] as the host molecule and glycine (Gly) as the guest, the interaction mode between the two in both an aqueous and solid phase was studied using 1H NMR spectroscopy and X-ray crystallography. Analysis of the 1H NMR spectra and crystal structure showed that CyH2Q[6] and Gly form a 1:2 host–guest inclusion compound.
Method for synthesizing cyclohexyl-modified cucurbit urils
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Paragraph 0024-0026, (2019/11/25)
The invention discloses a method for synthesizing cyclohexyl-modified cucurbit urils. The method comprises the steps: using 1,2-cyclohexanedione semihydrate, performing acidification by using H2SO4, HNO3, HCl and other inorganic acids or organic acids in water, performing a reaction on 1,2-cyclohexanedione semihydrate and urea so as to synthesize cyclohexyl-modified glycoluril, and further performing a reaction with paraformaldehyde so as to synthesize cyclohexyl-modified glycoluril diether and the fully-substituted cyclohexyl cucurbit urils. Characterization is carried out by means of X-ray single crystal diffraction, H MNR and the like. The method is simple, and has easy operation, the defects of cumbersome reaction steps, low reaction yield, environmental pollution and high cost of an original method can be overcome, the toxicity of selenium dioxide in the cucurbit urils is avoided, pollution is reduced, and the yield is improved.
