338415-39-7

Basic information

• Product Name: N-([2-(4-CHLOROPHENYL)IMIDAZO[1,2-A]PYRIDIN-3-YL]METHYL)-N,N-DIMETHYLAMINE
• Synonyms: N-([2-(4-CHLOROPHENYL)IMIDAZO[1,2-A]PYRIDIN-3-YL]METHYL)-N,N-DIMETHYLAMINE;[2-(4-CHLOROPHENYL)IMIDAZO[1,2-A]PYRIDIN-3-YL]-N,N-DIMETHYLMETHANAMINE;{[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]methyl}dimethylamine
• CAS NO: 338415-39-7
• Molecular Formula: C₁₆H₁₆ClN₃
• Molecular Weight: 285.77
• Mol File: 338415-39-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-([2-(4-CHLOROPHENYL)IMIDAZO[1,2-A]PYRIDIN-3-YL]METHYL)-N,N-DIMETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-([2-(4-CHLOROPHENYL)IMIDAZO[1,2-A]PYRIDIN-3-YL]METHYL)-N,N-DIMETHYLAMINE(338415-39-7)
• EPA Substance Registry System: N-([2-(4-CHLOROPHENYL)IMIDAZO[1,2-A]PYRIDIN-3-YL]METHYL)-N,N-DIMETHYLAMINE(338415-39-7)

Safety Data

• Hazardous Substances Data: 338415-39-7(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 38922-74-6 2-(4-chlorophenyl)imidazolo[1,2-a]pyridine 
• 124-40-3 dimethyl amine 
• 108-74-7 1,3,5-trimethyl-1,3,5-triazacyclohexane 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 17745-06-1 [2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]acetic acid 
• 82622-54-6 2-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylacetamide 
• 17744-99-9 2-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)acetonitrile 
• 21801-83-2 2-[2-(4-chloro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-acetamide 

Relevant articles and documents

Preparation method of imidazole [1, 2-a] pyridine-containing secondary amine and tertiary amine derivatives

The invention provides a preparation method of imidazo [1, 2-a] pyridine-containing secondary amine and tertiary amine derivatives from triazine compounds and imidazo [1, 2-a] pyridine, and relates to the field of medicinal chemistry. According to the present invention, the triazine compound is reacted with the imidazo [1, 2-a] pyridine compound, the Lewis acid catalysis is performed, the reaction conditions such as the reaction temperature and the reaction time are controlled, and the controllable cracking and the fixed-point selectivity of the triazine compound are utilized to synthesize different imidazo [1, 2-a] pyridine-containing secondary amine and tertiary amine derivatives, such that the synthesis method is simple, the multi-step reaction is not required, the product purity and yield are high, selectable substrate range is wide, and the preparation method can be well applied to the field of pharmacy.

A structure-activity relationship study of the affinity of selected imidazo[1,2-a]pyridine derivatives, congeners of zolpidem, for the ω1-subtype of the benzodiazepine receptor

A series of 6-substituted 2-aryl-N,N-dimethylimidazol [1,2-a]pyridine-3-acetamides, congeners of zolpidem and alpidem, was synthesized and tested in vitro for binding with the benzodiazepine receptor in the competition with 3H-zolpidem as an ω1-selective radioligand. Molecular electrostatic potential (MEP) and the HOMO and LUMO energies were calculated for the compounds by semi-empirical quantum chemistry methods. The lipophilicity parameter of the compounds, expressed as the logarithm of the octanol-water partition coefficient (log P), was calculated; alternatively, standard values of the Hansch hydrophobic substituent constants π were used. In agreement with earlier investigations on the benzodiazepine receptor ligands with a high preference for the ω1-subtype, a quantitative correlation of the biological data with molecular parameters has revealed a significant dependence (r=0.954) of the binding affinity (IC50) on the deepest MEP minimum, in this case associated with the amide carbonyl oxygen atom. The lipophilicity parameters were found to be of lower significance.