33857-66-8

Upstream product

• 2127-03-9 2,2'-dipyridyldisulphide 
• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 39031-14-6 thiopyridyl-benzisothiazole 1,1-dioxide 

Downstream Products

• 72635-82-6 N-(benzyloxycarbonyl)-L-valyl-L-threonine 
• 4817-95-2 N-(benzyloxycarbonyl)-L-valyl-L-phenylalanine methyl ester 
• 51827-14-6 N-[(Phenylmethoxy)carbonyl]-L-valyl-L-proline methyl ester 
• 47450-18-0 N-benzyloxycarbonyl-L-valyl-L-proline 
• 108543-83-5 N-(benzyloxycarbonyl)-L-valyl-O-(tert-butyldimethylsilyl)-L-threonine 
• 2766-17-8 ethyl N-(benzyloxycarbonyl)-L-valylglycinate 
• 19542-51-9 N-benzyloxycarbonyl-L-valyl-L-phenylalanine 
• 33857-85-1 N-benzyloxycarbonyl-L-valyl-L-leucine methyl ester 

Relevant academic research and scientific papers

Synthetic Studies on Antifungal Cyclic Peptides, Echinocandins. Stereoselective Total Synthesis of Echinocandin D via a Novel Peptide Coupling

Synthetic studies on the novel fungicidal oligopeptides, echinocandins (1b and 1c), are described.The constituent amino acids 5-8 were synthesized in a stereocontrolled manner from the chiral starting materials, 5a, 6a and 7a, respectively.The coupling of these amino acids was characterized by the use of unprotected amino acid as the C-terminal and 2-pyridyl thiol ester as the N-terminal, and the coupling was performed in the presence of 1-(trimethylsilyl)imidazole (TMSIm) or a catalytic amount of tert-amine to give C-terminal free dipeptides, 14 and 16a, respectively, which were converted to the pentapeptide 17a, a common intermediate for the synthesis of 1b and 1c.The synthesis of 1c was achieved by the cyclization of the hexapeptide 24b.

Synthesis of a new saccharin derivative (BID-SPy) and its utilization as a condensing reagent in the preparation of dipeptides

A new saccharin derivative, thiopyridyl-benzisothiazole 1,1-dioxide (BID-SPy, 2), has been prepared by the reaction of BID-Cl (1) and 2-mercaptopyridine, and utilized as a coupling reagent in the synthesis of amides and N-protected dipeptides.