Butanethioic acid, 3-methyl-2-[[(phenylmethoxy)carbonyl]amino]-, S-2-pyridinyl ester, (S)-

Base Information

• Chemical Name: Butanethioic acid, 3-methyl-2-[[(phenylmethoxy)carbonyl]amino]-, S-2-pyridinyl ester, (S)-
• CAS No.: 33857-66-8
• Molecular Formula: C18H20N2O3S
• Molecular Weight: 344.434
• Mol file: 33857-66-8.mol

Synonyms:

Chemical Property of Butanethioic acid, 3-methyl-2-[[(phenylmethoxy)carbonyl]amino]-, S-2-pyridinyl ester, (S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Butanethioic acid, 3-methyl-2-[[(phenylmethoxy)carbonyl]amino]-, S-2-pyridinyl ester, (S)-

There total 2 articles about Butanethioic acid, 3-methyl-2-[[(phenylmethoxy)carbonyl]amino]-, S-2-pyridinyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2'-dipyridyldisulphide (2127-03-9) + (S)-N-(benzyloxycarbonyl)valine (1149-26-4) → N-benzyloxycarbonyl-L-valine 2-pyridylthiol ester (33857-66-8)

Guidance literature:

With triphenylphosphine; In dichloromethane; for 3h; Yield given; Ambient temperature;

DOI:10.1016/S0040-4020(01)87959-X

Reference yield:

thiopyridyl-benzisothiazole 1,1-dioxide (39031-14-6) + (S)-N-(benzyloxycarbonyl)valine (1149-26-4) → N-benzyloxycarbonyl-L-valine 2-pyridylthiol ester (33857-66-8)

Guidance literature:

With triethylamine; In dichloromethane; for 2h; Ambient temperature;

Reference yield: 75.0%

methyl (2S)-2-amino-3-phenylpropanoate (2577-90-4) + N-benzyloxycarbonyl-L-valine 2-pyridylthiol ester (33857-66-8) → N-(benzyloxycarbonyl)-L-valyl-L-phenylalanine methyl ester (4817-95-2)

Guidance literature:

With trimethylaluminum; In dichloromethane; at 0 ℃; for 0.166667h;

DOI:10.1016/S0040-4039(99)02132-2

upstream raw materials:

thiopyridyl-benzisothiazole 1,1-dioxide

(S)-N-(benzyloxycarbonyl)valine

2,2'-dipyridyldisulphide

Downstream raw materials:

N-benzyloxycarbonyl-L-valyl-L-leucine methyl ester

N-(benzyloxycarbonyl)-L-valyl-L-threonine

N-benzyloxycarbonyl-L-valyl-L-phenylalanine

ethyl N-(benzyloxycarbonyl)-L-valylglycinate