33866-48-7

Basic information

• Product Name: 3-(4-CHLOROPHENYL)ISOXAZOL-5-AMINE
• Synonyms: OTAVA-BB BB7020410194;3-(4-CHLOROPHENYL)-5-ISOXAZOLAMINE;3-(4-CHLOROPHENYL)ISOXAZOL-5-AMINE;3-(4-CHLORO-PHENYL)-ISOXAZOL-5-YLAMINE;5-AMINO-3-(4-CHLOROPHENYL)ISOXAZOLE;BUTTPARK 23\04-63;5-Amino-3-(4-chlorophenyl)isoxazole ,97%;5-Amino-3-(4-chlorophenyl)oxazole
• CAS NO: 33866-48-7
• Molecular Formula: C₉H₇ClN₂O
• Molecular Weight: 194.62
• Product Categories: Halogenated Heterocycles;Heterocyclic Building Blocks;Isoxazoles;IsoxazolesBuilding Blocks;Building Blocks;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks
• Mol File: 33866-48-7.mol
• Article Data: 10

Chemical Properties

• Melting Point: 163-167 °C(lit.)
• Boiling Point: 404.5°Cat760mmHg
• Flash Point: 198.5°C
• Appearance: /
• Density: 1.342g/cm³
• Vapor Pressure: 9.38E-07mmHg at 25°C
• Refractive Index: 1.611
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(4-CHLOROPHENYL)ISOXAZOL-5-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-CHLOROPHENYL)ISOXAZOL-5-AMINE(33866-48-7)
• EPA Substance Registry System: 3-(4-CHLOROPHENYL)ISOXAZOL-5-AMINE(33866-48-7)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22
• Safety Statements: 24/25
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 33866-48-7(Hazardous Substances Data)

Usage

Chemical Properties

Light brown solid

InChI:InChI=1/C9H7ClN2O/c10-7-3-1-6(2-4-7)8-5-9(11)13-12-8/h1-5H,11H2

Upstream product

• 71707-43-2 (E)-2-chloro-3-(4-chlorophenyl)acrylonitrile 
• 28123-63-9 4-chlorobenzohydroximoyl chloride 
• 7335-27-5 ethyl 4-chlorobenzoate 
• 71426-50-1 Syn-α-Brom-p-chlor-acetophenon oxim 
• 151-50-8 potassium cyanide 
• 134140-88-8 5-Amino-4-carboxyethyl-3-(4-chlorphenyl)isoxazol 
• 4640-66-8 p-chlorobenzoylacetonitrile 

Downstream Products

• 134140-89-9 5-Amino-4-nitro-3-(4-chlorphenyl)isoxazol 
• 1216994-52-3 C₁₆H₁₁ClN₂O₃ 
• 33866-47-6 3-(4-chlorophenyl)-2H-azirine-2-carboxamide 
• 1316121-65-9 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid [3-(4-chloro-phenyl)-isoxazol-5-yl]-amide 

Relevant articles and documents

An enantioselective aza-Friedel-Crafts reaction of 5-aminoisoxazoles with isatin-derived: N -Boc ketimines

By employing a chiral phosphoric acid as a catalyst, an enantioselective aza-Friedel-Crafts reaction of 5-aminoisoxazoles with isatin-derived N-Boc ketimines was realized. The reaction provided a wide variety of novel 3-isoxazole 3-amino-oxindoles with good yields (up to 99%) and moderate to good enantioselectivities (up to 99%). The absolute configuration of one product was assigned by X-ray crystal structural analysis and a plausible reaction mechanism was proposed. In addition, a scale-up reaction was performed successfully. Finally, one product was subjected to Suzuki-Miyaura coupling with phenylboronic acid to afford the product in a moderate yield without erosion of the enantioselectivity. This journal is

Reactions of 5-Aminoisoxazoles with α-Diazocarbonyl Compounds: Wolff Rearrangement vs N-H Insertion

A highly chemoselective reaction between 5-aminoisoxazoles and α-diazocarbonyl compounds has been described. Both Wolff rearrangement and N-H insertion products can be obtained selectively by the judicious choice of reaction conditions. In the case of the

CYANOPYRROLIDINE DERIVATIVES WITH ACTIVITY AS INHIBITORS OF USP30

The present invention relates to substituted-cyanopyrrolidines of Formula (I) with activity as inhibitors of deubiquitilating enzymes, in particular, ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30), having utility in a variety