71426-50-1Relevant academic research and scientific papers
Asymmetric synthesis of nonracemic primary amines via spiroborate-catalyzed reduction of pure (E)- and (Z)-O-benzyloximes: Applications toward the synthesis of calcimimetic agents
Ou, Wenhua,Espinosa, Sandraliz,Meléndez, Héctor J.,Farré, Silvia M.,Alvarez, Jaime L.,Torres, Valerie,Martínez, Ileanne,Santiago, Kiara M.,Ortiz-Marciales, Margarita
, p. 5314 - 5327 (2013/07/25)
Highly enantiopure (1-aryl)- and (1-naphthyl)-1-ethylamines were synthesized by the borane-mediated reduction of single-isomeric (E)- and (Z)-O-benzyloxime ethers using the stable spiroborate ester derived from (S)-diphenyl valinol and ethylene glycol as the chiral catalyst. Primary (R)-arylethylamines were prepared by the reduction of pure (Z)-ethanone oxime ethers in up to 99% ee using 15% of catalyst. Two convenient and facile approaches to the synthesis of new and known calcimimetic analogues employing enantiopure (1-naphthalen-1-yl)ethylamine as chiral precursor are described.
Stereospecific synthesis and antimycobacterial activity of 1-aryl-2-(1H- imidazol-1-yl)-O-(aryl)-ethanoxime ethers E and Z oxiconazole analogs
Fioravanti, Rossella,Biava, Mariangela,Porretta, Giulio Cesare,Lampis, Giorgio,Maullu, Carlo,Pompei, Raffaello
, p. 249 - 266 (2007/10/03)
A stereospecific synthesis of antifungal imidazolylarylethanoxime ether derivatives is reported. The (E) and (Z)- assignments, respectively, were made on the basis of 1H-NMR-spectral data. The new derivatives are provided with in vitro antimyco
