3387-63-1

Basic information

• Product Name: 2-amino-6-chloro-9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine
• Synonyms: 2-amino-6-chloro-9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine
• CAS NO: 3387-63-1
• Molecular Weight: 614.014
• Mol File: 3387-63-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-amino-6-chloro-9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-6-chloro-9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine(3387-63-1)
• EPA Substance Registry System: 2-amino-6-chloro-9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine(3387-63-1)

Safety Data

• Hazardous Substances Data: 3387-63-1(Hazardous Substances Data)

Upstream product

• 6974-32-9 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose 
• 10310-21-1 2-Amino-6-chloropurin 
• 14215-97-5 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose 
• 1311109-56-4 2-tert-butoxycarbonylamino-6-chloro-9-(2’,3’,5’-tri-O-benzoyl-β-D-ribofuranosyl)purine 

Downstream Products

• 403842-37-5 C₃₁H₂₂ClIN₄O₇ 
• 2004-07-1 2-Amino-6-chloropurine riboside 
• 7803-88-5 6-O-methylguanosine 
• 2096-10-8 adenosine-2-amine 
• 35109-88-7 2-iodoadenosine 
• 90596-73-9 2-(1-hexynyl)adenosine 
• 141018-25-9 (3aR,4R,6R,6aR)-(6-(6-amino-2-iodo-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol 
• 39708-01-5 2-amino-6-ethoxy-9-(β-D-ribofuranosyl)-9H-purine 

Relevant articles and documents

SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

Disclosed herein are nucleosides, nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Filoviridae virus infection with one or more nucleosides and/or nucleotide analogs.

An efficient approach to the synthesis of nucleosides: Gold(I)-catalyzed N-glycosylation of pyrimidines and purines with glycosyl ortho-alkynyl benzoates

Persuaded with gold: The title reaction in the presence of [Ph 3PAuNTf2] (Tf=trifluoromethanesulfonyl) led conveniently to the corresponding nucleosides with excellent regioselectivity (see scheme). Even purine derivatives underwent this transformation owing to the mild conditions, which enabled the use of protecting groups that would not usually be compatible with N-glycosylation conditions. Copyright

N-alkoxysulfamide, N-hydroxysulfamide, and sulfamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases

A series of sulfamate surrogates of methionyl and isoleucyl adenylate have been investigated as MetRS and IleRS inhibitors by modifications of the sulfamate linker and adenine moieties. The discovery of 2-iodo Ile-NHSO2-AMP (58) as a potent Escherichia coli IleRS inhibitor revealed that a significant hydrophobic interaction between the 2-substituent of Ile-NHSO2-AMP and the adenine binding site of IleRS provided its high potency to the enzyme.