33876-85-6

Upstream product

• 2857-97-8 trimethylsilyl bromide 
• 18106-71-3 dimethyl benzoylphosphonate 
• 98-88-4 benzoyl chloride 

Downstream Products

• 6881-61-4 benzoylphosphonic acid 
• 115244-25-2 C₄₁H₃₉N₄O₁₃PS₂ 
• 145298-96-0 P,P'-dibenzoylpyrophosphonic dichloride 
• 145298-97-1 2-propyl hydrogen benzoylphosphonate 
• 22950-57-8 diisopropyl benzoylphosphonate 
• 115244-24-1 C₅₄H₆₃N₄O₁₄PSi 
• 115260-13-4 C₆₂H₅₆N₇O₁₃PS₂ 
• 89849-90-1 5'-O-dimethoxytritylthymidin-3'-yl 3'-O-(1,3-benzodithiol-2-yl)thymidin-5'-yl benzoylphosphonate 
• 115260-07-6 C₆₉H₆₇N₄O₁₆P 
• 115244-23-0 C₅₅H₅₃N₄O₁₅P 

Relevant academic research and scientific papers

One-pot synthesis of phosphinylphosphonate derivatives and their anti-tumor evaluations

This paper reports on the synthesis of new hydroxymethylene-(phosphinyl)phosphonates (HMPPs). A methodology has been developed to propose an optimized one-pot procedure without any intermediate purifications. Various aliphatic and (hetero)aromatic HMPPs were synthesized in good to excellent yields (53–98%) and the influence of electron withdrawing/donating group substitution on aromatic substrates was studied. In addition, the one-pot synthesis of HMPP was monitored by31P NMR spectroscopy, allowing effective control of the end of the reaction and identification of all phosphorylated intermediate species, which enabled us to propose a reaction mechanism. Optimized experimental conditions were applied to the preparation of biological relevant aminoalkyl-HMPPs. A preliminary study of the complexation to hydroxyapatite (bone matrix) was carried out in order to verify its lower affinity towards bone compared to bisphosphonate molecules. Moreover, in vitro anti-tumor activity study revealed encouraging antiproliferative activities on three human cancer cell lines (breast, pancreas and lung).

New efficient synthesis of 1-hydroxymethylene-1,1-bisphosphonate monomethyl esters

A new efficient procedure for the synthesis of 1-hydroxymethylene-1,1- bisphosphonate monomethyl esters in three steps from acid chlorides is reported here. Georg Thieme Verlag Stuttgart.

Novel approach to nucleoside-5′-(1-hydroxymethylene-1, 1-bisphosphonates): Synthesis of new AZT analogues

An efficient synthetic method of nucleoside-5′-(1-hydroxymethylene-1, 1-bisphosphonates) is reported here. The procedure was optimized with 3′-protected thymidine and then applied to synthesis of new AZT analogues. Copyright

THE REACTION OF BENZOYLPHOSPHONIC ACID WITH THIONYL CHLORIDE. THE FORMATION OF BENZOYLPHOSPHONIC DICHLORIDE AND P,P'-DIBENZOYLPYROPHOSPHONIC DICHLORIDE

The reaction of benzoylphosphonic acid (3) with thionyl chloride leads to the formation of benzoylphosphonic dichloride (5) and P,P'-dibenzoylpyrophosphonic dichloride (6).These products were identified by (31)P nmr spectra and through their products of a