33876-92-5

Basic information

• Product Name: N-(4-methoxyphenyl)-1H-imidazole-1-carboxamide
• Synonyms: N-(4-methoxyphenyl)-1H-imidazole-1-carboxamide
• CAS NO: 33876-92-5
• Molecular Weight: 217.227
• Mol File: 33876-92-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: N-(4-methoxyphenyl)-1H-imidazole-1-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methoxyphenyl)-1H-imidazole-1-carboxamide(33876-92-5)
• EPA Substance Registry System: N-(4-methoxyphenyl)-1H-imidazole-1-carboxamide(33876-92-5)

Safety Data

• Hazardous Substances Data: 33876-92-5(Hazardous Substances Data)

Upstream product

• 288-32-4 1H-imidazole 
• 5416-93-3 4-Methoxyphenyl isocyanate 
• 104-94-9 4-methoxy-aniline 
• 530-62-1 1,1'-carbonyldiimidazole 
• 18156-74-6 1-(Trimethylsilyl)imidazole 

Downstream Products

• 1378233-18-1 C₁₈H₂₀N₂O₄ 
• 900357-27-9 C₁₁H₁₆N₂O₃ 
• 3746-53-0 N-(4-metoxyphenyl)-N'-phenylurea 
• 288-32-4 1H-imidazole 
• 5416-93-3 4-Methoxyphenyl isocyanate 
• 1620286-06-7 N-(4,4-diethoxybutyl)-N'-(4-methoxyphenyl)urea 
• 1620286-12-5 2-(2-hydroxynaphth-1-yl)-N-(4-methoxyphenyl)pyrrolidine-1-carboxamide 
• 1415661-99-2 N-hydroxy-3-(4-(3-(4-methoxyphenyl)ureido)phenoxy)benzamide 
• 1415662-17-7 3-(4-(3-(4-methoxyphenyl)ureido)phenoxy)benzoic acid 
• 1415661-94-7 C₂₁H₁₉N₃O₅ 
• 1415662-09-7 4-(4-(3-(4-methoxyphenyl)ureido)phenoxy)benzoic acid 
• 1415662-04-2 ethyl 4-(4-(3-(4-methoxyphenyl)ureido)phenoxy)benzoate 
• 1415662-13-3 methyl 3-(4-(3-(4-methoxyphenyl)ureido)phenoxy)benzoate 

Relevant articles and documents

Promiscuity and selectivity in covalent enzyme inhibition: A systematic study of electrophilic fragments

Covalent ligand-target interactions offer significant pharmacological advantages. However, off-target reactivity of the reactive groups, which usually have electrophilic properties, must be minimized, and the selectivity of irreversible inhibitors is a crucial requirement. We therefore performed a systematic study to determine the selectivity of several electrophilic groups that can be used as building blocks for covalently binding ligands. Six reactive groups with modulated electrophilicity were combined with 11 nonreactive moieties, resulting in a small combinatorial library of 72 fragment-like compounds. These compounds were screened against a group of 11 enzyme targets to assess their selectivity and their potential for promiscuous binding to proteins. The assay results showed a considerably lower degree of promiscuity than initially expected, even for those members of the screening collection that contain supposedly highly reactive electrophiles.

Reaction of 1-aryl-3-(4,4-diethoxybutyl)ureas with phenols. Synthesis of 2-arylpyrrolidines

Acid-catalyzed reaction of phenols with 1-(4,4-diethoxybutyl)urea derivatives gave new 2-arylpyrrolidines containing 4-bromoresorcinol and hydroquinone fragments. The described reaction is advantageous due to its mild conditions and no necessity of using

Unprecedented "in water" imidazole carbonylation: Paradigm shift for preparation of urea and carbamate

The first "In Water" imidazolecarbonylation of amine is described. A one pot reaction of carbonylimidazolide in water with a nucleophile provides an efficient and general method for the preparation of urea, carbamates and thiocarbamates. Use of an anhydrous solvent and an inert atmosphere could be avoided. Product precipitate out from the reaction mixture and can be obtained in high purity by filtration, resulting in a simple and scalable method.