33879-72-0Relevant academic research and scientific papers
BENZIMIDAZOLONE DERIVED INHIBITORS OF BCL6
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Paragraph 00372, (2018/12/13)
The present invention relates to compounds of Formula I that function as inhibitors of BCL6 (B-cell lymphoma 6) activity: wherein X1, X2, R1, R2 and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.
Enantioselective synthesis of allylsilanes bearing tertiary and quaternary si-substituted carbons through Cu-catalyzed allylic alkylations with alkylzinc and arylzinc reagents
Kacprzynski, Monica A.,May, Tricia L.,Kazane, Stephanie A.,Hoveyda, Amir H.
, p. 4554 - 4558 (2008/09/17)
All sorts of allylsilanes including, for the first time, those that contain a Si-bonded quaternary carbon, were synthesized through efficient and highly enantioselective Cu-catalyzed asymmetric allylic alkylations. Reactions may involve dialkyl- as well as diarylzinc reagents and are promoted by various chiral N-heterocyclic carbene complexes.
Mutation and inhibition studies of mevalonate 5-diphosphate decarboxylase
Qiu, Yongge,Gao, Jinbo,Guo, Fei,Qiao, Yuqin,Li, Ding
, p. 6164 - 6168 (2008/04/03)
Mevalonate 5-diphosphate decarboxylase plays an important role in regulating cholesterol biosynthesis, which was studied through incubation with various synthetic substrate analogs and characterization of mutated enzymes. The results are potentially useful for further developing inhibitors that block the mevalonate pathway which is a drug target for treating cardiovascular disease and cancer.
ISOMERIZATION OF EPOXIDES TO ALLYLIC ALCOHOLS USING METHYLMAGNESIUM N-CYCLOHEXYLISOPROPYLAMIDE
Mosset, Paul,Manna, Sukumar,Viala, Jacques,Falck, J.R.
, p. 299 - 302 (2007/10/02)
The scope of methylmagnesium N-cyclohexylisopropylamide promoted isomerizations of epoxides to allylic alcohols is described.
