33902-32-8

Upstream product

• 475630-82-1 4-iodo-6-methoxy-3-(4-methoxyphenyl)isocoumarin 
• 490039-83-3 2-iodo-4-methoxybenzonitrile 
• 1369864-41-4 2-iodo-4-methoxybenzamide 
• 1431758-09-6 C₁₇H₁₅NO₃ 
• 100-07-2 4-methoxy-benzoyl chloride 

Downstream Products

• 550365-24-7 3-(4-hydroxyphenyl)-6-methoxyisocoumarin 

Relevant academic research and scientific papers

Synthetic method of isocoumarin compound

The invention belongs to the field of organic chemical synthesis, and particularly relates to a synthesis method of an isocoumarin compound. A compound shown in (A) and a compound shown in (B) react in a solvent under the action of a noble metal catalyst and a first additive to obtain a compound shown in (C); the noble metal catalyst is one or more of triruthenium dodecacarbonyl, a dichlorophenyl ruthenium (II) dimer and dichloro bis (4-methyl isopropyl phenyl) ruthenium (II); the first additive is one or more of silver tetrafluoroborate, silver hexafluoroantimonate, copper acetate, zinc acetate, silver trifluoromethanesulfonate, copper trifluoromethanesulfonate and zinc trifluoromethanesulfonate. The invention provides a simple and effective method for constructing the lactone compound, and the method does not need to additionally add an additive with a guiding effect, and can give consideration to the self-cyclization and cross-cyclization isocoumarin compound of sulfur ylide.

Ruthenium(II)-Catalyzed Construction of Isocoumarins via Dual C-H/C-C Activation of Sulfoxonium Ylides

A ruthenium(II)-catalyzed annulation between two molecules of sulfoxonium ylides is achieved, generating a variety of substituted isocoumarins in reasonable yields. This strategy features dual C-H/C-C activation in one pot and has a wide substrate scope and good functional group tolerance.

Ruthenium(II)-Catalyzed Homocoupling of Weakly Coordinating Sulfoxonium Ylides via C?H Activation/Annulations: Synthesis of Functionalized Isocoumarins

Homocoupling of weakly coordinating sulfoxonium ylides was accomplished via ruthenium (II) catalyzed C?H activation process. This strategy provides a convenient, efficient and step-economic method to access 3-substituted isocoumarins with good functional

Preparation method of substituted isocoumarin derivative (by machine translation)

The invention discloses a preparation method of a substituted isocoumarin derivative and, in particular, discloses a preparation method of a substituted isocoumarin derivative. When a carbon-carbon bond and a carbon hydrogen bond are cut off, a new carbon

Super acid catalysed sequential hydrolysis/cycloisomerization of o-(acetylenic)benzamides under microwave condition: Synthesis, antinociceptive and antiinflammatory activity of substituted isocoumarins

Synthesis of isocoumarins and related compounds via triflic acid promoted hydrolysis/cyclization sequence of 2-(alkynyl)benzamides under microwave condition was achieved. The substrate scope of the reaction was broad to include not only aromatic but also

Synthesis of 3-arylisocoumarins, including thunberginols A and B, unsymmetrical 3,4-disubstituted isocoumarins, and 3-ylidenephthalides via iodolactonization of methyl 2-ynylbenzoates or the corresponding carboxylic acids

3-Aryl-4-iodoisocoumarins, which were readily and efficiently prepared by regioselective iodolactonization of methyl 2-ynylbenzoates or the corresponding carboxylic acids, were used as precursors either to 3-arylisocoumarins, including naturally-occurring