490039-83-3

Upstream product

• 874-90-8 4-methoxybenzonitrile 
• 96-96-8 4-methoxy-2-nitroaniline 
• 38469-83-9 4-methoxy-2-nitro-benzonitrile 
• 38487-85-3 4-methoxyanthranilonitrile 

Downstream Products

• 1619256-47-1 4-methoxy-2-(2-methylallyl)benzonitrile 
• 1431758-12-1 C₁₁H₁₁NO₂ 
• 1431758-11-0 C₁₂H₁₃NO₂ 
• 1431758-09-6 C₁₇H₁₅NO₃ 
• 1431758-08-5 C₁₆H₁₃NO₂ 
• 1369864-41-4 2-iodo-4-methoxybenzamide 
• 33902-32-8 6-methoxy-3-(4-methoxyphenyl)-1H-2-benzopyran-1-one 
• 65908-33-0 6-methoxy-2,3-diphenyl-1H-inden-1-one 
• 874-90-8 4-methoxybenzonitrile 

Relevant academic research and scientific papers

Palladium-catalyzed highly selective ortho-halogenation (I, Br, Cl) of arylnitriles via sp2 C-H bond activation using cyano as directing group

A palladium-catalyzed ortho-halogenation (I, Br, Cl) of arylnitrile is described. The optimal reaction conditions were identified after examining various factors such as catalyst, additive, solvent, and reaction temperature. Using cyano as the directing group, the halogenation reaction gave good to excellent yields. The method is compatible to the arylnitriles with either electron-withdrawing or electron-donating groups. The reaction is available to the substrate in at least gram scale. The present method was successfully applied to the synthesis of the precursors of paucifloral F and isopaucifloral F.

Super acid catalysed sequential hydrolysis/cycloisomerization of o-(acetylenic)benzamides under microwave condition: Synthesis, antinociceptive and antiinflammatory activity of substituted isocoumarins

Synthesis of isocoumarins and related compounds via triflic acid promoted hydrolysis/cyclization sequence of 2-(alkynyl)benzamides under microwave condition was achieved. The substrate scope of the reaction was broad to include not only aromatic but also

Therapeutic Compounds and Their Use in Treating Diseases and Disorders

The invention provides novel therapeutic compounds, pharmaceutical compositions comprising these compounds, and methods for using these compounds and compositions to treat diseases and disorders, such as cancer.

Carbopalladation of nitriles: Synthesis of 2,3-diarylindenones and polycyclic aromatic ketones by the Pd-catalyzed annulation of alkynes and bicyclic alkenes by 2-iodoarenenitriles

2-Iodobenzonitrile, its derivatives, and various heterocyclic analogues undergo palladium(O)-catalyzed annulation onto diarylacetylenes or bicyclic alkenes to afford 2,3-diarylindenones and polycyclic aromatic ketones in very good to excellent yields. This reaction represents one of the first examples of the addition of an organopalladium moiety to the carbon-nitrogen triple bond of a nitrile. The reaction is compatible with a number of functional groups. A reaction mechanism, as well as a model accounting for the electronic effects of substituents on the aromatic ring of the nitrile, is proposed.