339091-38-2

Upstream product

• 190583-85-8 1,2-O-isopropylidene-3,5-di-O-benzyl-β-L-arabinofuranose 
• 103763-14-0 (3aR,5S,6S,6aR)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,2-dimethyltetrahydro-2H-furo[2,3-d][1,3]dioxol-6-ol 
• 103763-12-8 5-O-tert-butyldiphenylsilyl-α,β-L-arabinofuranose 
• 100-39-0 benzyl bromide 
• 532-20-7 L-arabinose 
• 67-56-1 methanol 
• 320592-15-2 1,4-anhydro-3,5-di-O-benzyl-2-deoxy-L-erythro-pent-1-enitol 
• 51885-64-4 1,2-O-isopropylidene-β-L-arabinofuranose 

Downstream Products

• 442514-57-0 1-O-methyl-2-deoxy-2-fluoro-L-arabinofuranoside 
• 622785-69-7 1-((2S,3S,4S,5S)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 
• 390824-26-7 methyl 3-O-benzyl-β-L-ribofuranoside 
• 390824-24-5 methyl 3,5-di-O-benzyl-2-O-methanesulfonyl-L-arabinofuranoside 

Relevant academic research and scientific papers

11-Step Total Synthesis of Pallambins C and D

The structurally intriguing terpenes pallambins C and D have been assembled in only 11 steps from a cheap commodity chemical: furfuryl alcohol. This synthesis, which features a redox-economic approach free of protecting-group manipulations, assembles all four-ring systems via a sequential cyclization strategy. Of these four-ring constructing operations, two are classical (Robinson annulation and Mukaiyama aldol) and two are newly devised. During the course of this work a method for the difunctionalization of enol ethers was developed, and the scope of this transformation was explored.

L-nucleoside compounds and application thereof

The invention discloses L-nucleoside compounds having the structure characteristic represented by the formula (I) or pharmaceutically acceptable salts thereof, and belongs to the technical field of pharmaceutical chemistry. The compounds can inhibit the activity of RNA viral polymerase, so the compounds can be used as potential drugs for prevention and treatment of infection of RNA viruses such as HCV, influenza virus, HRV (rhinovirus), RSV, Ebola virus, dengue virus, intestinal virus and the like.

A stereospecific synthesis of L-ribose and L-ribosides from D-galactose

An inexpensive D-galactose was converted into L-ribose and its derivatives via mild reaction conditions. The L-ribosyl donor was submitted to a glycosidation according to Vorbrüggen's conditions to give L-ribosides in high yields.