33912-39-9

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-chlorophenyl)-4-phenylazetidin-2-one is used as a potential pharmaceutical candidate for its anti-inflammatory and analgesic effects. Its pharmacological properties make it a promising agent for the treatment of various conditions that involve inflammation and pain.
Used in Medicinal Chemistry:
1-(4-chlorophenyl)-4-phenylazetidin-2-one is used as a compound in the field of medicinal chemistry for the development of new drugs and biologically active compounds. Its unique structure and properties allow for further research and potential applications in creating novel therapeutic agents.
Used in Organic Synthesis:
1-(4-chlorophenyl)-4-phenylazetidin-2-one is also used in the field of organic synthesis, where it can serve as a building block or intermediate for the synthesis of more complex molecules with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 105-36-2 ethyl bromoacetate 
• 780-21-2 N-(4-chlorobenzylidene)aniline 
• 19865-58-8 N-(4-chlorophenyl)-α-phenylnitrone 
• 75-20-7 calcium carbide 
• 932-98-9 1-chloro-4-nitroso-benzene 
• 152189-81-6 N-(4-chlorophenyl)-3-phenylpropanamide 
• 501-52-0 3-Phenylpropionic acid 
• 645-45-4 hydrocinnamic acid chloride 

Relevant academic research and scientific papers

Copper-Catalyzed Oxidative Benzylic C(sp3)?H Cyclization for the Synthesis of β-Lactams

β-Lactams are important structural motifs because of their ubiquity in natural products and pharmaceuticals. We report herein a Cu-catalyzed intramolecular oxidative C(sp3)?H amidation for the synthesis of β-lactams using tBuOOtBu. This method

Synthesis of Exclusively 4-Substituted β-Lactams through the Kinugasa Reaction Utilizing Calcium Carbide

A new Kinugasa reaction protocol has been elaborated for the one-pot synthesis of 4-substituted β-lactams utilizing calcium carbide and nitrone derivatives. Calcium carbide is thereby activated by TBAF·3H2O in the presence of CuCl/NMI. The ease of synthesis and use of inexpensive chemicals provides rapid access of practical quantities of β-lactams exclusively substituted at position 4.

Synthesis and Stereochemistry of 3-(α-Hydroxybenzyl)-1,4-diphenyl-2-azetidinones

Aldol reaction between benzaldehydes and 1,4-diphenyl-2-azetidinones 1 catalyzed by lithium diisopropylamide results in formation of the title compound The reactions give satisfactory yields and high diastereoselectivity at three centres in forming the αS