3392-01-6

Basic information

• Product Name: Z-MET-OSU
• Synonyms: N-CARBOBENZOXY-L-METHIONINE HYDROXYSUCCINIMIDE ESTER;Z-L-METHIONINE HYDROXYSUCCINIMIDE ESTER;Z-L-METHIONINE N-HYDROXYSUCCINIMIDE ESTER;Z-MET-OSU;Z-L-METHIONINE HYDROXYSUCCINIMIDESTER;[(S)-1-[[(2,5-Dioxo-1-pyrrolidinyl)oxy]carbonyl]-3-(methylthio)propyl]carbamic acid benzyl ester;N-[(N-Carboxy-L-methionyl)oxy]succinimide benzyl ester;Z-L-methionineN-hydroxysuccinimide ester≥ 96% (HPLC)
• CAS NO: 3392-01-6
• Molecular Formula: C₁₇H₂₀N₂O₆S
• Molecular Weight: 380.42
• Mol File: 3392-01-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.35g/cm³
• Refractive Index: 1.594
• CAS DataBase Reference: Z-MET-OSU(CAS DataBase Reference)
• NIST Chemistry Reference: Z-MET-OSU(3392-01-6)
• EPA Substance Registry System: Z-MET-OSU(3392-01-6)

Safety Data

• Hazardous Substances Data: 3392-01-6(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C17H20N2O6S/c1-26-10-9-13(16(22)25-19-14(20)7-8-15(19)21)18-17(23)24-11-12-5-3-2-4-6-12/h2-6,13H,7-11H2,1H3,(H,18,23)

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 1152-62-1 Cbz-Met-OH 
• 107960-02-1 1,2,2,2-tetrachloroethyl-(N-succinimidyl)carbonate 

Downstream Products

• 33857-84-0 N-(benzyloxycarbonyl)-L-methionyl-L-valine methyl ester 
• 78816-94-1 Z-Met-N-hydroxy-succinimidester 
• 110512-40-8 methyl N--8-amino-2,6-anhydro-3,8-dideoxy-D-glycero-D-talo-octonate 

Relevant articles and documents

Structure-Activity Study of 5-Substituted 1-Carbobenzoxy-2-iminohydantoins as Potential Anticonvulsant Agents

On the basis of our previous findings, a series of 5-substituted 2-iminohydantoins has been synthesized and tested for anticonvulsant activity to better understand the SAR of 2-iminohydantoins.Among the compounds tested, (S)-(+)-1-carbobenzoxy-2-iminohydantoin analogs with ethyl (6)-, n-propyl (7a)-, isopropyl (8)-, allyl (9)-, and sec-butyl (11)-substituted groups at the C5 of the iminohydanotin ring provided the best activities against the MES test with ED50 values in the range of 52-74 mg/kg.All of the above compounds except 8 also showed activity against the scMET test with ED50 values in the range of 141-223 mg/kg.All significantly active compounds (1, 6, 7a, 8, 9, and 11) possesed aliphatic hydrocarbon side chains of two- to three-carbon lengths at the C5 position.All of the compounds with no or minimal activity had either shorter or longer side chains.The compounds substituted at the C5 position by aryl groups, arylalkyl groups, or alkyl and arylalkyl groups containing heteroatoms also showed no activity against the MES and scMET tests.The results suggested that the C5 side chain with the correct stereochemistry in 2-iminohydantoins provides optimal anticonvulsant activity when the side chains are aliphatic hydrocarbons with a lenght, ignoring branchingg, of two to three carbons.

Design and Synthesis of Peptide Derivatives of a 3-Deoxy-D-manno-2-octulosonic Acid (KDO) Analogues as Novel Antibacterial Agents Acting upon Lipopolysaccharide Biosynthesis

On the basis of the knowledge that the amino acid 3 (8-amino-2,6-anhydro-3,8-dideoxy-D-glycero-D-talo-octonic acid) is a potent inhibitor of 3-deoxy-manno-octulosonate cytidylyltransferase, attempts were made to design derivatives that would act as antiba