33930-74-4

Upstream product

• 100-39-0 benzyl bromide 
• 491-30-5 1-hydroxyisoquinoline 
• 59168-21-7 2-benzyl-1-(2H)-isoquinoline ketone 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1297276-92-6 2-(3-((2-benzyl-1-oxo-1,2-dihydroisoquinolin-4-yl)methyl)-5-chloro-2-methyl-1H-indol-1-yl)acetic acid 
• 1297284-51-5 methyl 2-(3-((2-benzyl-1-oxo-1,2-dihydroisoquinolin-4-yl)methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetate 
• 1297284-53-7 methyl 2-(3-((2-benzyl-1-oxo-1,2-dihydroisoquinolin-4-yl)methyl)-5-chloro-2-methyl-1H-indol-1-yl)acetate 
• 1297284-52-6 methyl 2-(3-((2-benzyl-1-oxo-1,2-dihydroisoquinolin-4-yl)methyl)-2-methyl-1H-indol-1-yl)acetate 

Relevant academic research and scientific papers

INDOLE BASED RECEPTOR CRTH2 ANTAGONISTS

Disclosed are compounds of Formula (I): which are useful as antagonists of the CRTH2 receptors. Pharmaceutical compositions containing compounds of Formula (I) and the use of compounds of Formula (I) to treat diseases or disorders that are responsive to inhibition of the binding of endogenous ligands to the CRTH2 receptor are also disclosed. Methods for preparing and using these compounds are further described.