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339370-40-0

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339370-40-0 Usage

General Description

5-Bromo-2-fluorobenzenesulphonyl chloride 98% is a chemical compound commonly used as a reagent in organic synthesis. It is a sulfonyl chloride derivative with a bromine and fluorine atom on a benzene ring, making it a highly reactive and versatile reagent for various chemical reactions. 5-Bromo-2-fluorobenzenesulphonyl chloride 98% is widely used in pharmaceutical and agrochemical industries for the synthesis of complex molecules and also as a precursor in the production of other important chemicals. The high purity level of 98% makes it suitable for a wide range of advanced chemical applications, and its versatility makes it a valuable addition to the arsenal of organic reagents available to chemists.

Check Digit Verification of cas no

The CAS Registry Mumber 339370-40-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,3,9,3,7 and 0 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 339370-40:
(8*3)+(7*3)+(6*9)+(5*3)+(4*7)+(3*0)+(2*4)+(1*0)=150
150 % 10 = 0
So 339370-40-0 is a valid CAS Registry Number.

339370-40-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-Bromo-2-fluorobenzenesulfonyl chloride

1.2 Other means of identification

Product number -
Other names 5-Bromo-2-fluorobenzenesulphonyl chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:339370-40-0 SDS

339370-40-0Relevant articles and documents

COMPOUNDS AND COMPOSITIONS FOR USE IN TREATING SKIN DISORDERS

-

Paragraph 1006-1008, (2021/08/06)

Provided herein is a compound of formula (XXXII) or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer thereof or a physiologically functional derivative thereof, wherein R1, R2, R3, G, A, E, n, p, and q are defined herein. Also provided herein are compositions comprising a compound of formula (XXXII), and methods of using a compound of formula (XXXII), e.g., in the treatment or prevention of skin disorders.

Radiosynthesis and preliminary evaluation of 11C-labeled 4-cyclopropyl-7-(3-methoxyphenoxy)-3,4-dihydro-2H-benzo[e] [1,2,4] thiadiazine 1,1-dioxide for PET imaging AMPA receptors

Chen, Jiahui,Chen, Zhen,Collier, Lee,Deng, Xiaoyun,Fu, Hualong,Gan, Jiefeng,Gong, Jian,Liang, Steven H.,Rong, Jian,Shang, Jingjie,Shao, Tuo,Sun, Jiyun,Wang, Lu,Xu, Hao

supporting information, (2020/01/31)

The α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) belong to the family of ionotropic transmembrane receptors for glutamate (iGluRs) that are implicated in the pathology of neurological disorders and neurodegenerative diseases. Inspired by a recently developed positive allosteric modulator of AMPARs, 4-cyclopropyl-7-(3-methoxyphenoxy)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide (16; EC50 = 2.0 nM), we designed a new synthetic route for N-protected phenolic precursor 13 and efficiently radiolabeled a PET ligand [11C]AMPA-1905 ([11C]16) using a modified one-pot two-step strategy in high radiochemical yield and high molar activity. Preliminary in vivo evaluation was carried out to investigate the suitability of [11C]16 as a potential PET probe for AMPAR imaging.

Discovery of a novel series of potent and orally bioavailable phosphoinositide 3-kinase γ inhibitors

Leahy, James W.,Buhr, Chris A.,Johnson, Henry W. B.,Kim, Byung Gyu,Baik, Taegon,Cannoy, Jonah,Forsyth, Timothy P.,Jeong, Joon Won,Lee, Matthew S.,Ma, Sunghoon,Noson, Kevin,Wang, Longcheng,Williams, Matthew,Nuss, John M.,Brooks, Eric,Foster, Paul,Goon, Leanne,Heald, Nathan,Holst, Charles,Jaeger, Christopher,Lam, Scott,Lougheed, Julie,Nguyen, Lam,Plonowski, Arthur,Song, Joanne,Stout, Thomas,Wu, Xiang,Yakes, Michael F.,Yu, Peiwen,Zhang, Wentao,Lamb, Peter,Raeber, Olivia

experimental part, p. 5467 - 5482 (2012/09/25)

The phosphoinositide 3-kinases (PI3Ks) have been linked to an extraordinarily diversified group of cellular functions making these enzymes compelling targets for the treatment of disease. A large body of evidence has linked PI3Kγ to the modulation of autoimmune and inflammatory processes making it an intriguing target for drug discovery. Our high-throughput screening (HTS) campaign revealed two hits that were nominated for further optimization studies. The in vitro activity of the first HTS hit, designated as the sulfonylpiperazine scaffold, was optimized utilizing structure-based design. However, nonoptimal pharmacokinetic properties precluded this series from further studies. An overlay of the X-ray structures of the sulfonylpiperazine scaffold and the second HTS hit within their complexes with PI3Kγ revealed a high degree of overlap. This feature was utilized to design a series of hybrid analogues including advanced leads such as 31 with desirable potency, selectivity, and oral bioavailability.

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