340-71-6

Upstream product

• 400-36-2 trifluoroacetylacetic acid 
• 100-52-7 benzaldehyde 
• 57-13-6 urea 
• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 

Relevant academic research and scientific papers

Polyphosphate ester-mediated synthesis of dihydropyrimidines. Improved conditions for the Biginelli reaction

Dihydropyrimidines 7 are prepared in high yield by a one-pot condensation of aldehydes, acetoacetates, and ureas using a polyphosphate ester-mediated cyclocondensation reaction. Yields are significantly higher than utilizing classical Biginelli reaction c

Isolation, conformational analysis and X-Ray structure determination of a trifluoromethyl-stabilized hexahydropyrimidine - An intermediate in the Biginelli reaction

Hexahydropyrimidine-5-carboxylic acid ethyl ester (8) was obtained from Biginelli-type condensation of ethyl trifluoroacetoacetate with urea and benzaldehyde. The conformational features of this hexahydropyrimidine were investigated by computational and X

One-step solvent-free synthesis of fluoroalkyl-substituted 4-hydroxy-2-oxo(thioxo)hexahydropyrimidines in the presence of 1-butyl-3-methylimidazolium tetrafluoroborate

A convenient procedure has been developed for the synthesis of fluoroalkyl-substituted 6-aryl-4-hydroxy-2-oxo-(thioxo)hexahydropyrimidine derivatives by three-component condensation of fluorinated β-dicarbonyl compounds with aromatic aldehydes and urea or

Multicomponent synthesis and anticancer activity studies of novel 6-(Trifluoromethyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylate derivatives

A series of novel 6-(trifluoromethyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives were obtained in good yields from ethyl 4,4,4-trifluoro-3-oxobutanoate, urea, and aryl aldehyde via Biginelli multicomponent reaction. All the corresponding products 4a–4p were examined against four human cancer cell lines (A549, HepG2, COLO205 and DU145) and compounds 4e, 4i, and 4 m which showed promising anticancer activity have been identified.

Revisit to the Biginelli reaction: A novel and recyclable bioglycerol-based sulfonic acid functionalized carbon catalyst for one-pot synthesis of substituted 3,4-dihydropyrimidin-2-(1H)-ones

A simple and efficient synthetic protocol has been developed for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones by using a novel bioglycerol-based sulfonic acid functionalized carbon catalyst, devoid of moisture sensitive metal catalysts and corrosive acidic reagents. The developed method has the advantages of good to excellent yields, short reaction times, operational simplicity, and a recyclable catalyst. The catalyst can be prepared by a simple procedure from inexpensive and readily available glycerol and has been shown to be recoverable and reusable up to four cycles without any loss of activity.

One-pot synthesis of difluoromethyl-containing dihydropyrimidinones catalyzed by Yb(PFO)3 under solvent and dehydrating agent free conditions

The difluoromethyl-containing Biginelli dihydropyrimidinone derivatives were synthesized by a one-pot cyclocondensation of ethyl 4,4- difluoroacetoacetate, urea, and a variety of aldehydes in the presence of 5 mol% ytterbium perfluorooctanoate [Yb(PFO)su

Synthesis, characterization and biological evaluation of some dihydropyrimidinones

An efficient and facile one pot synthesis of 3,4-dihydropyrimidinones (Biginelli compounds) from divergent aldehydes, β-keto esters and urea or thiourea under solvent free conditions was performed using citric acid as catalyst, resulted in promising yield

NOVEL 2-OXO-1,2,3,4-TETRAHYDROPYRIMIDINES, BICYCLIC PYRIMIDINE DIONES AND IMIDAZOLIDINE-2,4-DIONES USEFUL AS INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITORS

The present invention relates to novel 2-oxo-l,2,3,4-tetrahydropyrimidines, bicyclic pyrimidine diones and imidizolidine-2,4-diones and methods useful as inhibitors of nitric oxide synthase.