340164-35-4Relevant academic research and scientific papers
A novel synthetic approach to benzo[h]chromones via sequential intramolecular alkynoyl transfer followed by 6-endo ring closure
Sakamoto, Katsuji,Honda, Erina,Ono, Noboru,Uno, Hidemitsu
, p. 1819 - 1823 (2000)
An intramolecular acyl transfer reaction took place on treatment of 1- methoxymethoxy-3-(2-alkynoyloxy)methyl-2-iodonaphthalenes with n-BuLi at - 78°C to give 1-methoxymethoxy-2-alkynoyl-3-hydroxymethylnaphthalenes in high yields. After protection of the hydroxymethyl group as benzoates, formation of a γ-pyrone ring was easily achieved by deprotection of the MOM group followed by spontaneous 6-endo-digonal ring closure under mild acidic conditions. (C) 2000 Elsevier Science Ltd.
