340232-52-2Relevant academic research and scientific papers
Mild Mn(OAc)3-Mediated Aerobic Oxidative Decarboxylative Coupling of Arylboronic Acids and Arylpropiolic Acids: Direct Access to Diaryl 1,2-Diketones
Lv, Wen-Xin,Zeng, Yao-Fu,Zhang, Shang-Shi,Li, Qingjiang,Wang, Honggen
supporting information, p. 2972 - 2975 (2015/06/30)
A simple and efficient method for the synthesis of diaryl 1,2-diketones has been developed. The reaction represents the first example of diaryl 1,2-diketones that are synthesized directly from arylboronic acids and arylpropiolic acids by a radical pathway in moderate to good yields. This reaction proceeds under mild reaction conditions and with good tolerance of a variety of functional groups. Preliminary mechanistic studies were conducted.
Trisubstituted imidazoles as mycobacterium tuberculosis glutamine synthetase inhibitors
Gising, Johan,Nilsson, Mikael T.,Odell, Luke R.,Yahiaoui, Samir,Lindh, Martin,Iyer, Harini,Sinha, Achyut M.,Srinivasa, Bachally R.,Larhed, Mats,Mowbray, Sherry L.,Karlén, Anders
supporting information; experimental part, p. 2894 - 2898 (2012/06/01)
Mycobacterium tuberculosis glutamine synthetase (MtGS) is a promising target for antituberculosis drug discovery. In a recent high-throughput screening study we identified several classes of MtGS inhibitors targeting the ATP-binding site. We now explore o
Oxidation of alkynes using PdCl2/CuCl2 in PEG as a recyclable catalytic system: One-pot synthesis of quinoxalines
Chandrasekhar,Reddy, N. Kesava,Kumar, V. Praveen
scheme or table, p. 3623 - 3625 (2010/08/13)
Alkynes were oxidized efficiently using the catalytic amount of PdCl 2 and CuCl2 in PEG-400 in the presence of water, providing excellent yields of the corresponding 1,2-diketones. A variety of alkynes were well-suited substrates for the oxidation under the described conditions. Further, the optimized conditions were successfully utilized for the one-pot synthesis of 2,3-disubstituted quinoxaline derivatives.
