957768-41-1Relevant academic research and scientific papers
Nickel-Catalyzed Hiyama-type Decarboxylative Coupling of Propiolic Acids and Organosilanes
Edwin Raja, Gabriel Charles,Irudayanathan, Francis Mariaraj,Kim, Han-Sung,Kim, Jimin,Lee, Sunwoo
, p. 5244 - 5249 (2016/07/06)
A Ni catalytic system was developed for the decarboxylative coupling reaction of alkynyl carboxylic acids with organosilanes. Ni(acac)2 and 1,10-phenanthroline showed the best result in the presence of CsF and CuF2 at 120 °C. This system tolerated the presence of alkyl, alkoxy, halogen, nitro, cyano, ketone, and ester functional groups. Moreover, the reaction with but-2-ynedioic acid and organosilane afforded the corresponding symmetrical diarylalkynes.
Trisubstituted imidazoles as mycobacterium tuberculosis glutamine synthetase inhibitors
Gising, Johan,Nilsson, Mikael T.,Odell, Luke R.,Yahiaoui, Samir,Lindh, Martin,Iyer, Harini,Sinha, Achyut M.,Srinivasa, Bachally R.,Larhed, Mats,Mowbray, Sherry L.,Karlén, Anders
supporting information; experimental part, p. 2894 - 2898 (2012/06/01)
Mycobacterium tuberculosis glutamine synthetase (MtGS) is a promising target for antituberculosis drug discovery. In a recent high-throughput screening study we identified several classes of MtGS inhibitors targeting the ATP-binding site. We now explore o
Highly convenient, clean, fast, and reliable Sonogashira coupling reactions promoted by aminophosphine-based pincer complexes of palladium performed under additive-and amine-free reaction conditions
Bolliger, Jeanne L.,Frech, Christian M.
experimental part, p. 891 - 902 (2009/12/01)
Sequential addition of 1,1',1″-phosphine-triyltripiperidine and 1,3-diaminobenzene or resorci-nol to toluene solutions of (cyclooctadiene) palladium dichloride [Pd(cod)(Cl)2] under nitrogen in "one pot" almost quantitatively yielded the aminophos-phine-based pincer complexes {[C6H3-2,6-(XP{piperi-dinyl}2) 2]Pd(Cl)} (X = NH 1; X = O 2). Complex 1 (and to a minor extent 2) proved to be efficient Sonogashira catalysts, which allow the quantitative coupling of various electronically deactivated and/or sterically hindered and functionalized aryl iodides and aryl bromides with several alkynes as coupling partners within very short reaction times and low catalyst loadings. Importantly, in contrast to most of the Sonogashira catalysts, which either are both air-and moisture-sensitive and/or require the addition of co-catalysts, such as copper(I) iodide [Cul], for ex- ample, or a large excess of an amine, the coupling reactions were carried out without the use of amines, co-catalysts or other aditives and without exclusion of air and moisture. Moreover, the desired products were exclusively formed (no side-products were detected) without employing an excess of one of the substrates. Ethylene glycol and potassium phosphate (K3PO4) were found to be the ideal solvent and base for this transformation. Experimental observations strongly indicate that palladium nanoparticles are not the catalytically active form of 1 and 2. On the other hand, their transformation into another homogeneous catalytically active species cannot be excluded.
Copper-catalyzed 2:1 Coupling reaction of arynes with alkynes
Yoshida, Hiroto,Morishita, Takami,Nakata, Hiromi,Ohshita, Joji
supporting information; experimental part, p. 373 - 376 (2009/08/08)
(Chemical Equation Presented) A formal insertion reaction of two molar amounts of arynes into a C-H bond of terminal alkynes is efficaciously catalyzed by copper(1) chloride, giving 2-alkynylbiaryls in one step.
