340255-27-8

Upstream product

• 21488-96-0 2-Methyl-2-[5-hydroxy-4-methyl-(3E)-pentenyl]-1,3-dioxolane 
• 110-93-0 6-Methyl-hept-5-en-2-on 
• 71846-54-3 (E)-7-hydroxy-6-methylhept-5-en-2-one 
• 330438-09-0 Methyl (4S,6R)-4-acetoxy-6-isopropenyl-8,8-dimethoxy-3-methyl-(2E)-octenate 
• 330438-11-4 Methyl (4S,6R)-4-hydroxy-6-isopropenyl-8,8-dimethoxy-3-methyl-(2E)-octenate 
• 330438-08-9 (3S,5R)-3-Acetoxy-5-isopropenyl-7,7-dimethoxyheptan-2-one 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 85757-72-8 (chloro-5 methyl-4 pentene-3 yl)-2 methyl-2 dioxolanne-1,3 
• 330438-12-5 (4S,6R)-6-Isopropenyl-8,8-dimethoxy-3-methyl-4-(tert-butyldiphenylsiloxyl)-(2E)-octen-1-ol 

Downstream Products

• 1027505-88-9 (-)-(3E,7E,11E)-13-(tert-Butyldiphenylsiloxyl)neocembrene 
• 340255-26-7 (3R,5S)-6,10-Dimethyl-3-isopropenyl-14-oxo-5-(tert-butyldiphenylsiloxyl)-(6E,10E)-pentadecadien-1-al 

Relevant academic research and scientific papers

First total synthesis and absolute configuration of (-)-13-hydroxy-11,12-epoxy-neocembrene

The first enantioselective total synthesis of (-)-13-hydroxy-11,12-epoxy-neocembrene (1), a naturally occurring cembranoid isolated from soft coral Sarcophyton trocheliophorum, was achieved via a general approach by employing intramolecular McMurry coupling as a key step from (S)-(+)-carvone. The absolute configuration of the epoxide function of 1 is concluded as (11S, 12S).

First enantioselective total synthesis of (-)-13-hydroxyneocembrene

The first enantioselective total synthesis of (-)-13-hydroxyneocembrene (1), a naturally occurring cembranoids isolated from soft coral Sarcophyton trocheliophorum, was achieved via a general approach by employing intramolecular McMurry coupling as a key step from (S)-(+)-carvone.