1027505-88-9

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 340255-27-8 2-Methyl-2-[(9S,11R)-11-isopropenyl-13,13-dimethoxy-4,8-dimethyl-9-(tert-butyldiphenylsiloxyl)-(3E,7E)-tridecadienyl]-1,3-dioxolane 
• 330438-12-5 (4S,6R)-6-Isopropenyl-8,8-dimethoxy-3-methyl-4-(tert-butyldiphenylsiloxyl)-(2E)-octen-1-ol 
• 330438-06-7 (4S,6R)-1-Chloro-6-isopropenyl-8,8-dimethoxy-3-methyl-4-(tert-butyldiphenylsiloxyl)-(2E)-octene 
• 330438-05-6 2-Methyl-2-[4-methyl-5-phenylsulfonyl-(3E)-pentenyl]-1,3-dioxolane 
• 85757-72-8 (chloro-5 methyl-4 pentene-3 yl)-2 methyl-2 dioxolanne-1,3 
• 71846-54-3 (E)-7-hydroxy-6-methylhept-5-en-2-one 
• 110-93-0 6-Methyl-hept-5-en-2-on 
• 21488-96-0 2-Methyl-2-[5-hydroxy-4-methyl-(3E)-pentenyl]-1,3-dioxolane 
• 340255-26-7 (3R,5S)-6,10-Dimethyl-3-isopropenyl-14-oxo-5-(tert-butyldiphenylsiloxyl)-(6E,10E)-pentadecadien-1-al 

Relevant academic research and scientific papers

First total synthesis and absolute configuration of (-)-13-hydroxy-11,12-epoxy-neocembrene

The first enantioselective total synthesis of (-)-13-hydroxy-11,12-epoxy-neocembrene (1), a naturally occurring cembranoid isolated from soft coral Sarcophyton trocheliophorum, was achieved via a general approach by employing intramolecular McMurry coupling as a key step from (S)-(+)-carvone. The absolute configuration of the epoxide function of 1 is concluded as (11S, 12S).