340258-61-9

Basic information

• Product Name: 2-Propenamide, N,3-bis(4-methoxyphenyl)-, (2E)-
• Synonyms: 4-Methoxy-zimtsaeure-p-anisidid;4-methoxy-cinnamic acid p-anisidide
• CAS NO: 340258-61-9
• Molecular Formula: C17H17NO3
• Molecular Weight: 283.327
• Mol File: 340258-61-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-Propenamide, N,3-bis(4-methoxyphenyl)-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenamide, N,3-bis(4-methoxyphenyl)-, (2E)-(340258-61-9)
• EPA Substance Registry System: 2-Propenamide, N,3-bis(4-methoxyphenyl)-, (2E)-(340258-61-9)

Safety Data

• Hazardous Substances Data: 340258-61-9(Hazardous Substances Data)

Usage

Also Known As

N-aryl acrylamide

Characteristics

Functional Groups: Contains two phenyl groups and an acrylamide functional group
Physical State: Colorless, odorless, crystalline solid
Solubility: Soluble in organic solvents

Applications

Used in the production of various polymers and materials
Employed in pharmaceutical research and manufacturing
Acts as a building block in the synthesis of other organic compounds

Upstream product

• 943-89-5 (E)-3-(4-methoxyphenyl)acrylic acid 
• 104-94-9 4-methoxy-aniline 
• 61916-60-7 3-((4-methoxyphenyl)amino)-3-oxopropanoic acid 
• 123-11-5 4-methoxy-benzaldehyde 
• 42996-84-9 p-methoxycinnamoyl chloride 
• 34446-64-5 (E)-3-(4-methoxyphenyl)propenoyl chloride 

Downstream Products

• 119990-33-9 2-amino-6-methoxy quinoline 
• 13676-02-3 2-chloro-6-methoxyquinoline 

Relevant articles and documents

An alternative way to analogues of avenanthramides and their antiradical activity

Abstract: The paper is devoted to the synthesis of arylidene malonic acid monoanilides and cinnamoyl anilines by condensation of malonic acid monoanilides with aromatic aldehydes. The presented synthetic route applies simple, cheap, and commercially available aromatic aldehydes and amines, thus overcoming traditional schemes, which involve derivatives of hydroxycinnamic acids. Besides, a mild and effective pyridine-mediated decarboxylation of carboxylic group at Csp2 in arylidene malonic acid monoanilides leading to cinnamoyl anilines is presented. The structures of obtained selected arylidene derivatives were approved additionally by X-ray analysis. The antiradical properties (2,2-diphenyl-1-picrylhydrazyl and galvinoxyl tests) and structure–activity relationships of the synthesized compounds were studied. Graphical abstract: [Figure not available: see fulltext.].

Copper-catalyzed direct transformation of secondary allylic and benzylic alcohols into azides and amides: An efficient utility of azide as a nitrogen source

A mild and convenient method for the synthesis of amides has been explored by using secondary alcohols, Cu(ClO4)2·6H2O as a catalyst, and trimethylsilyl azide (TMSN3) as a nitrogen source in the presence of 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) at ambient temperature. This method has been successfully adapted to the preparation of azides directly from their corresponding alcohols and offers excellent chemoselectivity in the formation of ω-halo azides and the azidation of allylic alcohols in the presence of a benzyl alcohol moiety. In addition, this strategy provides an opportunity to synthesize azides that can serve as precursors to β-amino acids. A mild and convenient method for the synthesis of amides has been explored by using secondary alcohols, Cu(ClO4)2·6H2O as a catalyst, and trimethylsilyl azide (TMSN3) as a nitrogen source in the presence of 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) at ambient temperature. This method has also been adapted to the preparation of azides directly from their corresponding alcohols.