3406-77-7

Basic information

• Product Name: (4-METHOXYPHENYL)THIO]ACETIC ACID
• Synonyms: Aceticacid, [(4-methoxyphenyl)thio]- (9CI); Acetic acid, [(p-methoxyphenyl)thio]-(6CI,7CI,8CI); (p-Methoxyphenylthio)acetic acid;S-(p-Methoxyphenyl)mercaptoacetic acid; [(4-Methoxyphenyl)sulfanyl]acetic acid;[(4-Methoxyphenyl)thio]acetic acid
• CAS NO: 3406-77-7
• Molecular Formula: C₉H₁₀O₃S
• Molecular Weight: 198.24
• Mol File: 3406-77-7.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 359°Cat760mmHg
• Flash Point: 170.9°C
• Appearance: /
• Density: 1.28g/cm³
• Vapor Pressure: 8.88E-06mmHg at 25°C
• Refractive Index: 1.59
• CAS DataBase Reference: (4-METHOXYPHENYL)THIO]ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (4-METHOXYPHENYL)THIO]ACETIC ACID(3406-77-7)
• EPA Substance Registry System: (4-METHOXYPHENYL)THIO]ACETIC ACID(3406-77-7)

Safety Data

• Hazardous Substances Data: 3406-77-7(Hazardous Substances Data)

Usage

General Description

(4-Methoxyphenyl)thio]acetic acid is a chemical compound that belongs to the class of thioacetic acids. It is made up of a benzene ring with a methoxy group and a thioacetic acid group attached to it. (4-METHOXYPHENYL)THIO]ACETIC ACID is commonly used as a building block in the synthesis of various organic compounds, especially in the pharmaceutical and agrochemical industries. It has various potential applications in the development of drugs and crop protection products due to its unique chemical properties. Overall, (4-Methoxyphenyl)thio]acetic acid is an important chemical reagent with a wide range of potential uses in the field of organic chemistry.

InChI:InChI=1/C9H10O3S/c1-12-7-2-4-8(5-3-7)13-6-9(10)11/h2-5H,6H2,1H3,(H,10,11)

Upstream product

• 3926-62-3 sodium monochloroacetic acid 
• 696-63-9 4-Methoxybenzenethiol 
• 105-36-2 ethyl bromoacetate 
• 79295-14-0 methyl 2-((4-methoxyphenyl)thio)acetate 
• 79-11-8 chloroacetic acid 

Downstream Products

• 108373-21-3 (3-bromo-4-methoxy-phenylsulfanyl)-acetic acid 
• 3937-99-3 p-methoxy-phenylsulphonylacetic acid 
• 1879-16-9 1-methoxy-4-methylsulfanyl-benzene 
• 5335-87-5 4,4'-dimethoxyphenyl disulfide 
• 696-63-9 4-Methoxybenzenethiol 
• 18851-20-2 {AgC₉H₁₀O₃S}⁽¹⁺⁾ 
• 3996-45-0 p-OMeC6H4SOCH2COOH 
• 101032-21-7 5,5'-dimethoxy-N,N'-ethylenebis(salicylideneaminato) manganese(III)(hexafluorophosphate) 
• 101032-25-1 5,5'-dinitro-N,N'-ethylenebis(salicylideneaminato) manganese(III)(hexafluorophosphate) 
• 3517-90-6 p-anisyl methyl sulfone 
• 3517-99-5 1-methoxy-4-(methylsulfinyl)benzene 

Relevant articles and documents

RETRACTED ARTICLE: Design, synthesis, and biological evaluation of heterotetracyclic quinolinone derivatives as anticancer agents targeting topoisomerases

A series of thiochromeno[2,3-c]quinolin-12-one derivatives with various substitutions were synthesized and evaluated as topoisomerase (Topo) inhibitors. Six (8, 10, 12, 14, 19, and 26) of 23 compounds showed strong inhibitory activities against Topo-media

FMS-LIKE TYROSINE KINASE INHIBITORS

The present invention relates to Fms-like tyrosine kinase (FLT3) inhibitors. The present invention provides novel 4-quinolinone derivatives used as FLT3 inhibitors and for treatment and/or prevention of tumors.

Importance of ground state stabilization in the oxovanadium(IV)-salophen mediated reactions of phenylsulfinylacetic acids by hydrogen peroxide – Non-linear Hammett correlation

A systematic study on the oxidative decarboxylation of a series of phenylsulfinylacetic acids (PSAA) by hydrogen peroxide with four oxovanadium(IV)-salophen catalysts in 100% acetonitrile medium is presented. The hydroperoxovanadium(V)-salophen generated from the reaction mixture is identified as the bonafide active oxidizing species. Introduction of electron donating groups (EDG) in the oxovanadium(IV)-salophen catalyst and electron withdrawing groups (EWG) in PSAA enhances the reactivity, whereas EWG in the catalyst and EDG in PSAA have a retarding effect on the reaction. A Hammett correlation displays a non-linear downward curvature, which consists of two intersecting straight lines and the ρ value shifts from small positive to moderately high as the substituents change from EWG to EDG. The importance of the ground state stabilization of PSAA is inferred from a linear Yukawa–Tsuno plot. Based on the observed substituent effects and the spectral changes, a mechanism involving electrophilic attack of PSAA on the nucleophilic peroxo oxygen atom of the vanadium complex in the rate determining step followed by oxygen atom transfer is proposed.