34066-62-1

Usage

Uses

Used in Organic Synthesis:
N-Methyl cyclobutylamine serves as a crucial component in organic synthesis, contributing to the creation of a variety of chemical compounds. Its unique structure allows it to participate in numerous chemical reactions, making it a versatile building block in the synthesis of new molecules.
Used as a Precursor in Pharmaceutical and Agrochemical Industries:
In the pharmaceutical and agrochemical sectors, N-Methyl cyclobutylamine is utilized as a precursor for the preparation of various products. Its reactivity and structural features make it suitable for the development of drugs and agrochemicals, enhancing their efficacy and properties.
Used in the Development of New Materials:
N-Methyl cyclobutylamine also plays a role in the development of innovative materials, where its cyclic amine structure can be integrated into the design of new compounds with specific properties. This application showcases its potential in material science and technology.
Used as a Ligand in Coordination Chemistry:
Furthermore, N-Methyl cyclobutylamine functions as a ligand in coordination chemistry, interacting with metal ions to form coordination compounds. This role is significant in the study and application of coordination compounds in various fields, including catalysis and medicinal chemistry.

Upstream product

• 1191-95-3 cyclobutanone 
• 74-89-5 methylamine 

Downstream Products

• 821800-33-3 C₂₈H₃₃N₅O₄ 
• 1384267-54-2 C₂₁H₃₂F₂N₂O 

Relevant academic research and scientific papers

Photometric Characterization of the Reductive Amination Scope of the Imine Reductases from Streptomyces tsukubaensis and Streptomyces ipomoeae

Imine reductases (IREDs) have emerged as promising enzymes for the asymmetric synthesis of secondary and tertiary amines starting from carbonyl substrates. Screening the substrate specificity of the reductive amination reaction is usually performed by time-consuming GC analytics. We found two highly active IREDs in our enzyme collection, IR-20 from Streptomyces tsukubaensis and IR-Sip from Streptomyces ipomoeae, that allowed a comprehensive substrate screening with a photometric NADPH assay. We screened 39 carbonyl substrates combined with 17 amines as nucleophiles. Activity data from 663 combinations provided a clear picture about substrate specificity and capabilities in the reductive amination of these enzymes. Besides aliphatic aldehydes, the IREDs accepted various cyclic (C4–C8) and acyclic ketones, preferentially with methylamine. IR-Sip also accepted a range of primary and secondary amines as nucleophiles. In biocatalytic reactions, IR-Sip converted (R)-3-methylcyclohexanone with dimethylamine or pyrrolidine with high diastereoselectivity (>94–96 % de). The nucleophile acceptor spectrum depended on the carbonyl substrate employed. The conversion of well-accepted substrates could also be detected if crude lysates were employed as the enzyme source.

Preparation process of aminoacetamide derivative

Disclosed herein are novel processes for preparing aminoacetamide derivatives, wherein: (1) a secondary amine is reacted with a 2-haloacetamide in the presence or absence of at least one solvent selected from water, lower alcohols, aromatic solvents and acetic acid esters; (2) an N-benzylideneamine derivative is reacted with dimethyl sulfate or diethyl sulfate to form a secondary amine, and this secondary amine is then reacted with a 2-haloacetamide; and (3) a primary amine is reacted with benzaldehyde to form an N-benzylideneamine derivative, this product is then reacted with dimethyl sulfate or diethyl sulfate to form a secondary amine, and this secondary amine is further reacted with a 2-haloacetamide. The 2-aminoacetamide derivatives are useful as intermediates for the preparation of novel antibiotics.