340696-16-4

Upstream product

• 309927-64-8 2-benzoyl-4,5-dimethoxy-1-(4-methylphenylsulfonamido)benzene 
• 91-16-7 1,2-dimethoxybenzene 
• 4038-14-6 3,4-dimethoxybenzophenone 
• 255896-36-7 (4,5-dimethoxy-2-nitrophenyl)-(phenyl)methanone 
• 39996-22-0 (2-amino-4,5-dimethoxyphenyl)-(phenyl)methanone 
• 98-88-4 benzoyl chloride 
• 5653-40-7 2-Amino-4,5-dimethoxybenzoic acid 
• 26759-46-6 methyl 2-amino-4,5-dimethoxybenzoate 
• 71089-34-4 methyl 4,5-dimethoxy-2-(p-toluenesulfonamido)benzoate 
• 871563-17-6 N-(2-hydroxymethyl-4,5-dimethoxyphenyl)-4-methylbenzenesulfonamide 
• 886499-20-3 N-(2-formyl-4,5-dimethoxyphenyl)-4-methylbenzenesulfonamide 
• 591-51-5 phenyllithium 
• 100-58-3 phenylmagnesium bromide 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 309927-65-9 4-methyl-N-{4,5-dimethoxy-2-[(5-methylfuran-2-yl)(phenyl)methyl]phenyl}benzenesulfonamide 
• 340696-26-6 2-[5-ethyl-2-furyl(phenyl)methyl]-4,5-dimethoxy-1-(4-methylphenylsulfonamido)benzene 
• 924635-59-6 2-[5-(tert-butyl)-2-furyl(phenyl)methyl]-4,5-dimethoxy-1-(4-methylphenylsulfonamido)benzene 
• 924635-61-0 4,5-dimethoxy-2-[5-(4-methylphenyl)-2-furyl(phenyl)methyl]-1-(4-methylphenylsulfonamido)benzene 
• 309927-66-0 4-[5,6-dimethoxy-1-(4-methylphenylsulfonyl)-3-phenyl-1H-2-indolyl]-2-butanone 
• 927403-61-0 (3E)-4-[5,6-dimethoxy-1-(4-methylphenyl)sulfonyl-3-phenyl-1H-indol-2-yl]but-3-en-2-one 
• 1613378-08-7 2-{4-[5,6-dimethoxy-1-(4-methylphenyl)sulfonyl-3-phenyl-1H-indol-2-yl]-2-oxobutyl}isoindole-1,3(2H)-dione 
• 1613378-07-6 N-{4-[5,6-dimethoxy-1-(4-methylphenyl)sulfonyl-3-phenyl-1H-indol-2-yl]-2-oxobutyl}-3,4-dimethoxybenzamide 
• 1613378-06-5 N-{4-[5,6-dimethoxy-1-(4-methylphenyl)sulfonyl-3-phenyl-1H-indol-2-yl]-2-oxobutyl}-4-nitrobenzamide 
• 1613378-05-4 N-{4-[5,6-dimethoxy-1-(4-methylphenyl)sulfonyl-3-phenyl-1H-indol-2-yl]-2-oxobutyl}benzamide 

Relevant academic research and scientific papers

Intramolecular Palladium-Catalyzed Oxidative Amination of Furans: Synthesis of Functionalized Indoles

Unconventional modification of palladium-catalyzed oxidative amination where a furan ring serves as a masked olefin is described. The designed chemical process provides 2-(2-acylvinyl)indole derivatives with up to a 93% yield and excellent E-selectivity. A highly reactive α,β-unsaturated carbonyl moiety of the obtained compounds allows for accessing various heteroaromatic scaffolds through simple synthetic procedures.

Broensted acid-catalyzed one-pot synthesis of indoles from o-aminobenzyl alcohols and furans

Broensted acid-catalyzed one-pot synthesis of indoles from o-aminobenzyl alcohols and furans has been developed. This method operates via the in situ formation of aminobenzylfuran, followed by its recyclization into the indole core. The method proved to be efficient for substrates possessing different functional groups, including -OMe, -CO2Cy, and -Br. The resulting indoles can easily be transformed into diverse scaffolds, including 2,3- and 1,2-fused indoles, and indoles possessing an α,β-unsaturated ketone moiety at the C-2 position.

Simple route to 3-(2-indolyl)-1-propanones via a furan recyclization reaction

A simple route to 1-R-3-(2-indolyl)-1-propanones has been elaborated based on recyclization of 2-(2-aminobenzyl)furan derivatives. Being a modification of the Reissert indole synthesis, our approach employs the furan ring as a source of carbonyl function. This approach is general and allows varying of substituents in aromatic ring as well as in 3-position of indole nucleus.