N-[2-(HYDROXY-PHENYLMETHYL)-4,5-DIMETHOXY-PHENYL]-4-METHYL-BENZENESULFONAMIDE

Base Information

• Chemical Name: N-[2-(HYDROXY-PHENYLMETHYL)-4,5-DIMETHOXY-PHENYL]-4-METHYL-BENZENESULFONAMIDE
• CAS No.: 340696-16-4
• Molecular Formula: C22H23NO5S
• Molecular Weight: 413.494
• Mol file: 340696-16-4.mol

Synonyms:2-hydroxy(phenyl)methyl-4,5-dimethoxy-1-(4-methylphenylsulfonamido)benzene;N-[2-(Hydroxy-phenyl-methyl)-4,5-dimethoxy-phenyl]-4-methyl-benzenesulfonamide;

Chemical Property of N-[2-(HYDROXY-PHENYLMETHYL)-4,5-DIMETHOXY-PHENYL]-4-METHYL-BENZENESULFONAMIDE

Chemical Property:

• PSA: 93.24000
• LogP: 5.04850

Purity/Quality:

N-(2-(Hydroxy(phenyl)methyl)-4,5-dimethoxyphenyl)-4-methylbenzenesulfonamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(HYDROXY-PHENYLMETHYL)-4,5-DIMETHOXY-PHENYL]-4-METHYL-BENZENESULFONAMIDE

There total 12 articles about N-[2-(HYDROXY-PHENYLMETHYL)-4,5-DIMETHOXY-PHENYL]-4-METHYL-BENZENESULFONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-benzoyl-4,5-dimethoxy-1-(4-methylphenylsulfonamido)benzene (309927-64-8) → N-(4,5-dimethoxy-2-(hydroxy(phenyl)methyl)phenyl)-4-methylbenzenesulfonamide (340696-16-4)

Guidance literature:

With sodium tetrahydroborate; In ethanol; Heating;

DOI:10.1016/j.tet.2006.10.056

Reference yield: 76.0%

N-(2-formyl-4,5-dimethoxyphenyl)-4-methylbenzenesulfonamide (886499-20-3) + phenyllithium (591-51-5) → N-(4,5-dimethoxy-2-(hydroxy(phenyl)methyl)phenyl)-4-methylbenzenesulfonamide (340696-16-4)

Guidance literature:

In tetrahydrofuran; at -78 ℃;

DOI:10.1021/jo402132p

Reference yield:

phenylmagnesium bromide (100-58-3) + p-toluenesulfonyl chloride (98-59-9) + 2-Amino-4,5-dimethoxybenzoic acid (5653-40-7) → N-(4,5-dimethoxy-2-(hydroxy(phenyl)methyl)phenyl)-4-methylbenzenesulfonamide (340696-16-4)

Guidance literature:

p-toluenesulfonyl chloride; 2-Amino-4,5-dimethoxybenzoic acid; With triethylamine; In tetrahydrofuran; water; at 20 ℃; for 6h;

With 4-methyl-morpholine; N,O-dimethylhydroxylamine*hydrochloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 0 - 20 ℃; for 18h;

phenylmagnesium bromide; Further stages;

DOI:10.1021/acs.joc.8b02470

upstream raw materials:

2-benzoyl-4,5-dimethoxy-1-(4-methylphenylsulfonamido)benzene

1,2-dimethoxybenzene

3,4-dimethoxybenzophenone

(4,5-dimethoxy-2-nitrophenyl)-(phenyl)methanone

Downstream raw materials:

4-methyl-N-{4,5-dimethoxy-2-[(5-methylfuran-2-yl)(phenyl)methyl]phenyl}benzenesulfonamide

2-[5-ethyl-2-furyl(phenyl)methyl]-4,5-dimethoxy-1-(4-methylphenylsulfonamido)benzene

2-[5-(tert-butyl)-2-furyl(phenyl)methyl]-4,5-dimethoxy-1-(4-methylphenylsulfonamido)benzene

4,5-dimethoxy-2-[5-(4-methylphenyl)-2-furyl(phenyl)methyl]-1-(4-methylphenylsulfonamido)benzene