3407-93-0Relevant academic research and scientific papers
Synthesis and antiproliferative activity of new hybrids bearing neocryptolepine, acridine and α-aminophosphonate scaffolds
Ahmed, Abdullah A. S.,Awad, Hanem M.,El-Sayed, Ibrahim El-Tantawy,El Gokha, Ahmed A.
, p. 1211 - 1221 (2020/01/29)
Synthesis of novel α-aminophosphonate hybrids 8a–f was accomplished by the reaction of 11-phenoxy-4-formylneocryptolepine 3, aminoalkylamino acridines 6a–f and diphenyl phosphite 7 in the presence of lithium perchlorate as Lewis acid catalyst in methanol.
Design, synthesis and evaluation of acridin-9-yl hydrazide derivatives as BACE-1 inhibitors
Jain, Priti,Wadhwa, Pankaj K.,Jadhav, Hemant R.
, p. 1507 - 1513 (2016/07/06)
BACE-1, an aspartyl protease is implicated in Alzheimer’s disease. In this paper, we report BACE-1 inhibitory potential of acridin-9-yl hydrazide derivatives, known to inhibit other aspartyl proteases. The derivatives were designed based on the docking st
Synthesis of substituted acridinyl pyrazoline derivatives and their evaluation for anti-inflammatory activity
Chandra, Trilok,Garg, Neha,Lata, Suman,Saxena,Kumar, Ashok
experimental part, p. 1772 - 1776 (2010/06/21)
A rapid preparation of compounds (1-24), with the objective of discovering novel and potent anti-inflammatory agent. All the compounds exhibited anti-inflammatory and analgesic activities at the dose 50 mg/kg p.o. The compound 1-(2′,4′-Chloroacridine-9′-yl)-3-(5′-pyridine-4-yl)-(1,3,4-oxadiazol-2-yl-thiomethyl)-pyrazole-5-one 24 showed better anti-inflammatory and analgesic activities at the three graded dose of 25, 50 and 100 mg/kg p.o.
Stereochemistry, tautomerism, and reactions of acridinyl thiosemicarbazides in the synthesis of 1,3-thiazolidines
Balentova, Eva,Imrich, Jan,Bernat, Juraj,Sucha, Lucia,Vilkova, Maria,Pronayova, Nad'a,Kristian, Pavol,Pihlaja, Kalevi,Klika, Karel D.
, p. 645 - 656 (2007/10/03)
Acridin-9-yl hydrazine upon treatment with various isothiocyanates (RNCS, R = methyl, allyl, phenyl, p-methoxy phenyl, and p-nitro phenyl) yielded the corresponding thiosemicarbazides with acridine substituted on the carbazide-type side. The alkyl-substit
