34074-20-9Relevant academic research and scientific papers
Hydrosilane-Promoted Facile Deprotection of tert-Butyl Groups in Esters, Ethers, Carbonates, and Carbamates
Ikeda, Takuya,Zhang, Zhenzhong,Motoyama, Yukihiro
, p. 673 - 677 (2019)
Combination of PdCl2 with 1,1,3,3-tetramethyldisiloxane in the presence of activated carbon was found to be an effective catalyst system for the cleavage reaction of C?O bond of O?t-Bu moieties. The present catalytic reaction offers a practical method for the deprotection of tert-butyl esters, tert-butyl ethers, O-Boc, and N-Boc derivatives under mild conditions. The addition of activated carbon in the reaction mixture was proved to be crucial for not only sustaining the catalytic activity but also trapping the palladium species after the reaction. (Figure presented.).
Pincer Ruthenium Catalyzed Intramolecular Silylation of C(sp 2)-H Bonds
Fang, Huaquan,He, Qiaoxing,Liu, Guixia,Huang, Zheng
supporting information, p. 2468 - 2472 (2017/11/04)
Reported herein is a highly efficient intramolecular silylation of aromatic C-H bonds catalyzed by a pincer ruthenium complex, giving benzoxasiloles under relatively mild reaction conditions with broad substrate scope and low catalyst loadings. The silylation product can be further converted into a biaryl product by Pd-catalyzed HiyamaDenmark cross-coupling reactions.
Incorporation of carbon dioxide into phthalides: Via ligand-free copper-catalyzed direct carboxylation of benzoxasiloles
Nguyen, Thanh V. Q.,Rodríguez-Santamaría, José A.,Yoo, Woo-Jin,Kobayashi, Shu
supporting information, p. 2501 - 2505 (2017/07/17)
The direct carboxylation of benzoxasiloles with carbon dioxide proceeded smoothly under mild conditions using copper iodide as a catalyst to afford phthalides after an acid work-up. Broad substrate scope and application of this methodology for the synthesis of natural products highlight the synthetic utility of this protocol.
