340771-05-3Relevant academic research and scientific papers
Discovery of FK453, a novel non-xanthine adenosine A1 receptor antagonist
Akahane, Atsushi,Katayama, Hirohito,Mitsunaga, Takafumi,Kita, Yasuhiro,Kusunoki, Takahiro,Terai, Takao,Yoshida, Keizo,Shiokawa, Youichi
, p. 2059 - 2062 (1996)
Novel 2-phenylpyrazolo[1,5-a]pyridine-3-acryloylamides were synthesized and evaluated for diuretic activities. FK453 (1d), the most potent compound in this series, was found to be a potent and selective adenosine A1 receptor antagonist, whereas 1e, the (S)-enantiomer of FK453, was a weak and non-selective adenosine antagonist.
