56983-95-0

Basic information

• Product Name: Pyrazolo[1,5-a]pyridine, 2-phenyl-
• Synonyms: 2-phenyl-3-azaindolizine;2-phenylpyrazolopyridine
• CAS NO: 56983-95-0
• Molecular Formula: C13H10N2
• Molecular Weight: 194.236
• Mol File: 56983-95-0.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: Pyrazolo[1,5-a]pyridine, 2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrazolo[1,5-a]pyridine, 2-phenyl-(56983-95-0)
• EPA Substance Registry System: Pyrazolo[1,5-a]pyridine, 2-phenyl-(56983-95-0)

Safety Data

• Hazardous Substances Data: 56983-95-0(Hazardous Substances Data)

Upstream product

• 61890-25-3 1-phenyl-2-(2-pyridinyl)ethylamine 
• 76943-42-5 2,4,6-Trimethyl-benzenesulfonate1-amino-2-phenylethynyl-pyridinium; 
• 7732-18-5 water 
• 7338-94-5 1,3-diphenyl-2-propynone 
• 110-86-1 pyridine 
• 1206884-59-4 2-(E)-styryl-N-benzoyliminopyridinium ylide 
• 23031-08-5 benzoyl(pyridin-1-ium-1-yl)amide 
• 588-72-7 [(E)-2-bromoethenyl]benzene 
• 98-81-7 1-bromovinylbenzene 
• 3240-11-7 Phenylacetylene-d1 
• 13146-23-1 copper(I) phenylacetylenide 
• 274-56-6 3-azaindolizine 
• 591-50-4 iodobenzene 
• 16205-44-0 Pyrazolo<1,5-a>pyridin-3-carbonsaeureethylester 

Downstream Products

• 127717-34-4 bis(2-phenylpyrazolo<1,5-a>pyrid-3-yl)methane 
• 115748-41-9 phenylbis(2-phenylpyrazolo<1,5-a>pyrid-3-yl)methane 
• 121491-39-2 ethyl (E)-3-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)acryloylate 
• 1610529-27-5 1-(2-phenyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)urea 

Relevant articles and documents

Regioselective Metalation and Functionalization of the Pyrazolo[1,5- a]pyridine Scaffold Using Mg- and Zn-TMP Bases

A regioselective functionalization of the pyrazolo[1,5-a]pyridine scaffold using Mg- and Zn-TMP bases (TMP = 2,2,6,6-tetramethylpiperidyl) in the presence or absence of BF3·OEt2 is described. Also, various functionalized pyrazolo[1,5-a]pyridines bearing an ester function (and an NHBoc or ethyl group) are magnesiated and functionalized, leading to polysubstituted heterocycles. Additionally, a sulfoxide directed ortho-metalation, followed by the transition-metal-free amination of a pyrazolo[1,5-a]pyridine sulfoxide, using a magnesium amide, is reported.

BICYCLIC HETEROARYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS

Compounds of Formula I or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.

Synthesis of pyrazolo[1,5-a]pyridines by thermal intramolecular cyclization

Thermal intramolecular cyclization of N-amino-2-alkynylpyridines was developed for facile and versatile synthesis of pyrazolo[1,5-a]pyridines. Simply heating N-amino-2-alkynylpyridines in acetic acid provided pyrazolo[1,5-a] pyridines in excellent yield.