3408-16-0Relevant academic research and scientific papers
COMPOUNDS USEFUL AS KINASE INHIBITORS
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Paragraph 00235; 00381; 00450, (2017/07/14)
This invention relates to novel compounds. The compounds of the invention are tyrosine kinase inhibitors. Specifically, the compounds of the invention are useful as inhibitors of Bruton's tyrosine kinase (BTK).The invention also contemplates the use of the compounds for treating conditions treatable by the inhibition of Bruton's tyrosine kinase, for example cancer, lymphoma, leukemia and immunological diseases.
New synthesis of fluorinated pyrazoles
Surmont, Riccardo,Verniest, Guido,De Kimpe, Norbert
supporting information; scheme or table, p. 4648 - 4651 (2010/12/19)
A new synthesis of fluorinated pyrazoles, a class of compounds with potential in medicinal chemistry, is described. The treatment of benzoylfluoroacetonitrile with hydrazine yielded the expected new 3-amino-4-fluoropyrazole, while the analogous reaction of α-cyano-α, α-difluoroketones with hydrazine in refluxing isopropanol surprisingly gave rise to 3-unsubstituted 4-fluoropyrazoles via an unprecedented mechanism. The isolation of intermediate hydrazine adducts led to a mechanistic rationale for this transformation.
CONFORMATIONAL BEHAVIOUR AND E/Z ISOMERIZATION OF N-ACYL AND N-AROYLHYDRAZONES
Palla, Gerardo,Predieri, Giovanni,Domiano, Paolo,Vignali, Carlo,Turner, Walter
, p. 3649 - 3654 (2007/10/02)
The stereochemical behaviour of N-acyl and N-aroylhydrazones of aromatic aldehydes, of pyruvates and of acetone, in polar and less polar solvents, has been studied by HPLC and by NMR techniques.Z/E Geometrical isomers and cis/trans amide conformers have been found for N-acylhydrazones, while for N-aroylhydrazones only geometrical isomers were detected.Energy barriers of isomers are reported, and solvent effects are discussed with regard to hydrogen bond interactions.
