340816-25-3Relevant academic research and scientific papers
Synthetic and biological activity evaluation studies on novel 1,3-diarylpropenones
Mukherjee, Shubhasish,Kumar, Vijayendra,Prasad, Ashok K.,Raj, Hanumantharao G.,Bracke, Marc E.,Olsen, Carl E.,Jain, Subhash C.,Parmar, Virinder S.
, p. 337 - 345 (2007/10/03)
Fourteen novel C-prenylated and O-allylated 1,3-diarylpropenones (chalcones) were synthesized by Claisen-Schmidt condensation reaction of C-prenylated/O-allylated acetophenones with appropriate aldehydes; twelve of these model chalcones were screened in an assay based on the confrontation of invasive human MCF-7/6 mammary carcinoma cells with fragments of normal embryonic chick heart in vitro. Out of the twelve chalcones tested, three were found to exhibit potent anti-invasive activity. Some of these chalcones and their precursor acetophenones were also tested for inhibition of initiation of lipid peroxidation in rat liver microsomes; a prenylated acetophenone carrying two methoxy groups and two free phenolic hydroxy functions was found to be a potential antioxidant.
