340816-26-4Relevant academic research and scientific papers
Synthesis of 3′, 4′, 5, 6, 7-pentamethoxy-8-C-prenylflavone
Hossain, M. Amzad,Ismail, Zhari
experimental part, p. 11 - 14 (2010/08/20)
3′, 4′, 5, 6, 7-Pentamethoxy-8-C-prenylflavone, isolated from the leaves of Malaysian Orthosiphon stamineus, was synthesized starting with treating 2, 4, 5, 6-tetrahydroxyacetophenone with dimethyl sulphate which yielded several other minor compounds as well. The synthesized title compound is identical in all respects with the natural sample.
Synthesis of 5,6,7,3′-tetramethoxy-4′-hydroxy-8-C-prenylflavone
Hossain, M. Amzad,Ismail, Zhari
, p. 413 - 415 (2007/10/03)
5,6,7,3-Tetramethoxy-4′-hydroxy-8-C-prenylflavone 5 isolated from the leaves of Malaysian Orthosiphon stamineus has been synthesized by synthetic route. 2,4,5,6-Tetrahydroxyacetophenone 1 on treatment with dimethyl sulphate affords 2-hydroxy-4, 5, 6-trime
Synthetic and biological activity evaluation studies on novel 1,3-diarylpropenones
Mukherjee, Shubhasish,Kumar, Vijayendra,Prasad, Ashok K.,Raj, Hanumantharao G.,Bracke, Marc E.,Olsen, Carl E.,Jain, Subhash C.,Parmar, Virinder S.
, p. 337 - 345 (2007/10/03)
Fourteen novel C-prenylated and O-allylated 1,3-diarylpropenones (chalcones) were synthesized by Claisen-Schmidt condensation reaction of C-prenylated/O-allylated acetophenones with appropriate aldehydes; twelve of these model chalcones were screened in an assay based on the confrontation of invasive human MCF-7/6 mammary carcinoma cells with fragments of normal embryonic chick heart in vitro. Out of the twelve chalcones tested, three were found to exhibit potent anti-invasive activity. Some of these chalcones and their precursor acetophenones were also tested for inhibition of initiation of lipid peroxidation in rat liver microsomes; a prenylated acetophenone carrying two methoxy groups and two free phenolic hydroxy functions was found to be a potential antioxidant.
