340981-80-8Relevant articles and documents
Pyrrolidine nucleic acids: DNA/PNA oligomers with 2-hydroxy/aminomethyl-4-(thymin-1-yl)pyrrolidine-N-acetic acid
Kumar, Vaijayanti,Pallan, Pradeep S.,Meena,Ganesh, Krishna N.
, p. 1269 - 1272 (2001)
(equation presented) Synthesis of pyrrolidine-based chiral positively charged DNA analogues is reported. The synthesis of (2S,4S) and (2R,4R) thymin-1-ylpyrrolidine-N-acetic acid, its site specific incorporation in PNA:DNA chimera and PNA, and the study o
Pyrrolidine PNA-DNA chimeric oligonucleotides with extended backbone
Kumar, Vaijayanti A.,Meena
, p. 1101 - 1104 (2007/10/03)
Cis-D-2-hydroxy-4-thymin-1-yl-pyrrolidine propionic acid unit is used to make PNA-DNA dimer block that is incorporated in DNA sequences at selected positions. Since the amide linkage is shorter than phosphodiester linkage, insertion of an extra atom in th