341007-56-5

Upstream product

• 118-48-9 isatoic anhydride 
• 104-88-1 4-chlorobenzaldehyde 
• 100-46-9 benzylamine 
• 873-76-7 para-Chlorobenzyl alcohol 
• 5471-20-5 2-amino-N-benzylbenzamide 

Relevant academic research and scientific papers

Cu(II) complex-decorated hybrid nanomaterial: a retrievable catalyst for green synthesis of 2,3-dihydroquinazolin-4(1H)-ones

The significant stability of magnetic core and ? OH functional groups on the surface of silica-coated cobalt ferrite (CoFe2O4@SiO2) nanoparticles make it a good candidate for functionalization and catalytic application. In

2,3-dihydro-4(1H)-quinazolinone compound as well as medicine composition and application thereof

The invention relates to a 2,3-dihydro-4(1H)-quinazolinone compound as well as a medicine composition and application thereof. The 2,3-dihydro-4(1H)-quinazolinone compound has the main technical scheme that the structural general formula of the 2,3-dihydro-4(1H)-quinazolinone compound is shown as the formula (I) in the description; R1 is one of the following groups of hydrogen, methyl, methoxyl and halogen; R2 is one of the following groups of phenyl, a first group obtained by substituting at least one hydrogen in the phenyl by a substituent group, a pyridine group, a second group obtained bysubstituting at least one hydrogen in the pyridine group by a substituent group, a thiophene group, a furan group, saturated alicyclic hydrocarbon or first chain hydrocarbon; R3 is one of the following groups of phenyl, a third group obtained by substituting at least one hydrogen in the phenyl by a substituent group, a pyridine group, a thiophene group, a furan group, saturated alicyclic hydrocarbon and second chain hydrocarbon. The quinazolinone compound is mainly designed and synthesized; the compound can be used for preparing TRPC4 inhibitors or agonists, and preparing diabetes treatment medicine.

The synthesis of 2,3-dihydroquinazoline-4(1H)-one and dihydroisoindolo[2,1-a]quinazoline-5,11-dione derivatives in the presence of imidazolium ionic liquid sulfonic acid functionalized SBA-15: A novel feature of SBA-15

Imidazole-based ionic liquid-supported on SBA-15 (ImIL-Sul-SBA-15) as a novel heterogeneous catalyst was designed, synthesized and characterized by FT-IR, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and Brunauer-Emmett-Teller (BET) analysis. This novel nano structure was used for the synthesis of various 2,3-dihydroquinazoline-4(1H)-one and dihydroisoindolo[2,1-A]quinazoline-5,11-dione derivatives via three-component reaction between isatoic anhydride, amines and aromatic aldehydes at 50 °C in ethanol and water mixture as solvent. We found the synthetic imidazolium ionic liquid sulfonic acid functionalized SBA-15 as a convenient catalyst for this methodology. The catalyst performs the reaction in mild reaction conditions, and can easily be separated from the reaction mixture by simple filtration, with no need to tedious purification steps. Formula parented.

Reaction of benzyl alcohols, isatoic anhydride, and primary amines mediated by I2/K2CO3 in water: A new and green approach for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones

An efficient synthesis of 2,3-dihydroquinazolin-4(1H)-ones proceeding via a three-component reaction between benzyl alcohols, isatoic anhydride, and primary amines in the presence of iodine and potassium carbonate is reported. This protocol allows the straightforward preparation of the titled products using readily available benzyl alcohols instead of unstable aldehydes under mild oxidative conditions.

ZnO nanoparticles catalyzed efficient one-pot three-component synthesis of 2,3-disubstituted quinalolin-4(1H)-ones under solvent-free conditions

ZnO nanoparticles were prepared and applied as a favorable catalyst in three-component one-pot cyclocondensation reaction of isatoic anhydride with amines and aldehydes to afford the corresponding 2,3-disubstituted quinalolin-4(1H)-ones in good yields. Reactions occurred under solvent-free conditions in high atom economy.