34176-15-3

Upstream product

• 20628-06-2 2-hydroxy-4,5-dimethoxyacetophenone 
• 100-52-7 benzaldehyde 
• 40357-53-7 (E)-1-(2-hydroxy-4,5-dimethoxyphenyl)-3-phenylprop-2-en-1-one 
• 2033-89-8 3,4-dimethoxyphenol 
• 37486-24-1 3-(3,4-dimethoxyphenoxy) propanonitrile 
• 54013-49-9 2,3-dihydro-6,7-dimethoxy-4H-1-benzopyran-4-one 
• 98-80-6 phenylboronic acid 

Relevant academic research and scientific papers

Synthesis of Flavanones via Palladium(II)-Catalyzed One-Pot β-Arylation of Chromanones with Arylboronic Acids

A total of 47 flavanones were expediently synthesized via one-pot β-arylation of chromanones, a class of simple ketones possessing chemically unactivated β sites, with arylboronic acids via tandem palladium(II) catalysis. This reaction provides a novel route to various flavanones, including natural products such as naringenin trimethyl ether, in yields up to 92percent.

Synthesis and evaluation of neuroprotective selenoflavanones

The physicochemical properties and antioxidant activity of a molecule could be improved by the substitution of an oxygen atom in a molecule with selenium. We synthesized selenoflavanones and flavanones to evaluate their neuroprotective effects. The selenoflavanones showed improved physicochemical properties, suggestive of the ability to pass through the blood-brain barrier (BBB). They showed in vitro antioxidant effects against hydrogen peroxide, and did not result in severe cytotoxicity. Moreover, infarction volumes in a transient ischemia mouse model were significantly reduced by the selenoflavanone treatments.