40357-53-7

Upstream product

• 20628-06-2 2-hydroxy-4,5-dimethoxyacetophenone 
• 64-17-5 ethanol 
• 100-52-7 benzaldehyde 
• 2033-89-8 3,4-dimethoxyphenol 
• 102-92-1 cinnamoyl chloride 

Downstream Products

• 14227-15-7 (2E)-1-(2',4',5'-trimethoxyphenyl)-3-phenyl-2-propen-1-one 
• 34176-15-3 6,7-dimethoxy-2-phenylchroman-4-one 
• 26964-27-2 6.7-Dimethoxyflavone 

Relevant academic research and scientific papers

Synthesis and evaluation of neuroprotective selenoflavanones

The physicochemical properties and antioxidant activity of a molecule could be improved by the substitution of an oxygen atom in a molecule with selenium. We synthesized selenoflavanones and flavanones to evaluate their neuroprotective effects. The selenoflavanones showed improved physicochemical properties, suggestive of the ability to pass through the blood-brain barrier (BBB). They showed in vitro antioxidant effects against hydrogen peroxide, and did not result in severe cytotoxicity. Moreover, infarction volumes in a transient ischemia mouse model were significantly reduced by the selenoflavanone treatments.

Novel chromenone derivatives having substituted biphenyl group and a pharmaceutical composition for prevention or treatment of allergic diseases compring the same

The present invention relates to: a novel chromenone derivative compound capable of effectively suppressing an allergic immune response by inhibiting signal transduction mediated by thymic stromal lymphopoietin (TSLP); and a pharmaceutical composition capable of fundamentally preventing or treating various allergic diseases by using the same.COPYRIGHT KIPO 2021