341956-74-9Relevant academic research and scientific papers
POSITIVE ALLOSTERIC MODULATORS OF THE DELTA-OPIOID RECEPTOR
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Page/Page column 9, (2016/07/05)
Described are the discovery, synthesis and pharmacological characterization of δ-opioid receptor-selective positive allosteric modulators (δ PAMs). These δ PAMs may increase the affinity and/or efficacy of the orthosteric agonists leu-enkephalin and SNC80, as measured by β-arrestin recruitment and adenylyl cyclase inhibition. The compounds may be useful pharmacological tools to probe the molecular pharmacology of the δ receptor and to explore the therapeutic potential of δ PAMs in diseases such as chronic pain and depression.
Efficient preparation of 9-aryl-1,8-dioxo-octahydroxanthenes catalyzed by nano-TiO2 with high recyclability
Khazaei, Ardeshir,Reza Moosavi-Zare, Ahmad,Mohammadi, Zahra,Zare, Abdolkarim,Khakyzadeh, Vahid,Darvishi, Ghasem
, p. 1323 - 1326 (2013/03/14)
9-Aryl-1,8-dioxo-octahydroxanthene derivatives are synthesized by the reaction of arylaldehydes with dimedone (5,5-dimethyl-1,3-cyclohexanedione) in the presence of nano-TiO2 as an efficient and heterogeneous catalyst under solvent-free conditi
Ultrasound promoted rapid and green synthesis of 1,8-dioxo-octahydroxanthenes derivatives using nanosized MCM-41-SO3H as a nanoreactor, nanocatalyst in aqueous media
Rostamizadeh, Shahnaz,Amani, Ali Mohammad,Mahdavinia, Gholam Hossein,Amiri, Gelareh,Sepehrian, Hamid
experimental part, p. 306 - 309 (2010/12/19)
An efficient and green procedure has been developed for the synthesis of 1,8-dioxo-octahydroxanthenes derivatives. The reaction was carried out in water under ultrasound irradiation, using nanosized MCM-41-SO3H. In this method, several types of
