34239-38-8

Upstream product

• 802294-64-0 propionic acid 
• 98-86-2 acetophenone 
• 61967-11-1 3-methyl-2-phenyl-pent-4-en-2-ol 
• 98-88-4 benzoyl chloride 
• 106836-55-9 (E)-4-Methyl-5-oxo-5-phenyl-3-pyrrolidin-1-yl-pent-2-enoic acid methyl ester 
• 106836-52-6 (5S,6S)-5-Methyl-6-phenyl-4-pyrrolidin-1-yl-5,6-dihydro-pyran-2-one 
• 14366-97-3 (2R*,3S*)-2-methyl-3-phenyl-1,3-butanediol 
• 40309-46-4 3-hydroxy-2-methyl-3-phenylbutyric acid ethyl ester 

Downstream Products

• 14366-99-5 (2RS,3RS)-methyl 2-methyl-3-hydroxy-3-phenylbutyrate 

Relevant academic research and scientific papers

Irreversible aldolization of ketones with bisdicyclohexylboron enediolates

Unlike the reported reversible addition of ketone enolborinates to ketones, the aldolization of ketones with bisboron enediolates derived from carboxylic acids proceeds without difficulty. A variety of α,β,β-trisubstituted-β-hydroxy acids have been thus s

Indenone synthesis. Improved synthetic protocol and effect of substitution on the intramolecular Friedel-Crafts acylation

An improved protocol for the construction of substituted indenones is presented. Also the effect of substitution on the intramolecular Friedel-Crafts acylation was noted. Specifically, if there is no substitution at the 2-position of the indenone poor yields of cyclized material were obtained, if at all, while the substitution of a methyl or ethyl group greatly improved the yield of cyclized material. Placement of a large group (e. g., benzyl) resulted in a diminuation of the improved yield. The new synthetic procedure could, in principle, allow for the construction of 2,3-disubstituted indenones. One example of this reaction mode was presented.

A New Protocol for the Diastereoselective Formation of Lactones from either Achiral or Chiral Vinylogous Urethanes

The condensations of vinylogous urethanes, with or without a chiral auxiliary, and a variety of acid chlorides are described.Treatment of these acylated products with either L-Selectride or organometallic reagents leads, with high diastereoselectivity, to lactone products.

A Case of Highly Diastereoselective Addition to Unsymmetrical Ketones: lk-Addition of (2-Alkenyl)triphenoxytitanium Derivatives

(2-Butenyl)-, (4-methyl-2-pentenyl)-, and (2-heptenyl)triphenoxytitanium (2a-c) add to dialkyl, alkyl aryl-, and alkinyl aryl ketones to give high yields of tertiary homoallylic alcohols (5-12), which are diastereomerically enriched up to 98percent.Config