34253-01-5

Basic information

• Product Name: METHYL PYRIMIDINE-5-CARBOXYLATE
• Synonyms: RARECHEM AL BF 1377;METHYL PYRIMIDINE-5-CARBOXYLATE;5-Pyrimidinecarboxylic acid, methyl ester (6CI,7CI,8CI,9CI);5-Pyrimidicarboxylic acid methyl ester;5-Pyrimidinecarboxylic acid methyl ester;Nsc77421;5-Methoxycarbonyl-pyrimidine
• CAS NO: 34253-01-5
• Molecular Formula: C₆H₆N₂O₂
• Molecular Weight: 138.12
• Product Categories: PYRIMIDINE;Building Blocks;Heterocyclic Building Blocks;Pyrimidines
• Mol File: 34253-01-5.mol

Chemical Properties

• Melting Point: 76-81 °C
• Boiling Point: 224.3 °C at 760 mmHg
• Flash Point: 89.4 °C
• Appearance: /
• Density: 1.213 g/cm³
• Vapor Pressure: 0.092mmHg at 25°C
• Refractive Index: 1.513
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.13±0.10(Predicted)
• CAS DataBase Reference: METHYL PYRIMIDINE-5-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL PYRIMIDINE-5-CARBOXYLATE(34253-01-5)
• EPA Substance Registry System: METHYL PYRIMIDINE-5-CARBOXYLATE(34253-01-5)

Safety Data

• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 34253-01-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
Methyl pyrimidine-5-carboxylate is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the creation of diverse medicinal compounds, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Production:
In the agrochemical industry, Methyl pyrimidine-5-carboxylate serves as a vital component in the production of certain pesticides and other crop protection agents. Its incorporation enhances the effectiveness of these products, supporting agricultural productivity and crop health.
Used in Organic Chemistry Research:
Methyl pyrimidine-5-carboxylate is employed as a research compound in organic chemistry. It is used to explore novel chemical reactions and mechanisms, furthering the understanding of organic processes and potentially leading to the discovery of new chemical entities with practical applications.
Used in Biological and Pharmacological Studies:
Due to its potential biological and pharmacological activities, Methyl pyrimidine-5-carboxylate is also used in studies aimed at elucidating its interactions with biological systems. This research can provide insights into its therapeutic potential and guide the development of new treatments based on its properties.

InChI:InChI=1/C6H6N2O2/c1-10-6(9)5-2-7-4-8-3-5/h2-4H,1H3

Upstream product

• 4595-61-3 pyrimidine-5-carboxylic acid 
• 4595-59-9 5-bromopyrimidine 
• 71-23-8 propan-1-ol 
• 3375-31-3 palladium diacetate 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 

Downstream Products

• 176240-74-7 methyl 2-isopropylpyrimidine-5-carboxylate 
• 4595-61-3 pyrimidine-5-carboxylic acid 
• 40929-42-8 pyrimidine-5-carbohydrazide 
• 40929-49-5 pyrimidine-5-carboxamide 

Relevant articles and documents

Inhibitors of protein isoprenyl transferases

Compounds having the formula or a pharmaceutically acceptable salt thereof wherein R1is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L2—, and (i) heterocyclic-L2—; R2is selected from (a) (b) —C(O)NH—CH(R14)—C(O)OR15, (d) —C(O)NH—CH(R14)—C(O)NHSO2R16, (e) —C(O)NH—CH(R14)-tetrazolyl, (f) —C(O)NH-heterocyclic, and (g) —C(O)NH—CH(R14)—C(O)NR17R18; R3is substituted or unsubstituted heterocyclic or aryl, substituted or unsubstituted cycloalkyl or cycloalkenyl, and —P(W)RR3RR3′; R4is hydrogen, lower alkyl, haloalkyl, halogen, aryl, arylakyl, heterocyclic, or (heterocyclic)alkyl; L1is absent or is selected from (a) —L4—N(R5)—L5—, (b) —L4—O—L5—, (c) —L4—S(O)n—L5— (d) —L4—L6—C(W)—N(R5)—L5—, (e) —L4—L6—S(O)m—N(R5)—L5—, (f) —L4—N(R5)—C(W)—L7—L5—, (g) —L4—N(R5)—S(O)p—L7—L5—, (h) optionally substituted alkylene, (i) optionally substituted alkenylene, (j) optionally substituted alkynylene (k) a covalent bond, (l) and (m) are inhibitors of protein isoprenyl transferases. Also disclosed are protein isoprenyl transferase inhibiting compositions and a method of inhibiting protein isoprenyl transferases.

Quinolones as gonadotropin releasing hormone (GnRH) antagonists: Simultaneous optimization of the C(3)-aryl and C(6)-substituents

A series of 3-arylquinolones was prepared and evaluated for their ability to act as gonadotropin releasing hormone (GnRH) antagonists. A variety of substitution patterns of the 3-aryl substituent are described. The 3,4,5-trimethylphenyl substituent (23h) was found to be optimal. (C) 2000 Elsevier Science Ltd. All rights reserved.

Muscarinic agonists

Substituted 1,4,5,6 -tetrahydropyrimidine compositions, substituted 1,2,3,6-tetrahydropyrimidine compositions and substituted 3,4,5,6-tetrahydropyridine compositions are disclosed. They are useful for stimulating muscarinic receptors including, for example, treating the symptoms of cognitive disorders, especially impared memory, which are associated with decreased acetylcholine synthesis and cholinergic cell degeneration.