34277-78-6

Basic information

• Product Name: N-(carbamoylcarbamothioyl)benzamide
• CAS NO: 34277-78-6
• Molecular Formula: C₉H₉N₃O₂S
• Molecular Weight: 223.2517
• Mol File: 34277-78-6.mol
• Article Data: 5

Chemical Properties

• Density: 1.387g/cm³
• Refractive Index: 1.653
• CAS DataBase Reference: N-(carbamoylcarbamothioyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(carbamoylcarbamothioyl)benzamide(34277-78-6)
• EPA Substance Registry System: N-(carbamoylcarbamothioyl)benzamide(34277-78-6)

Safety Data

• Hazardous Substances Data: 34277-78-6(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 532-55-8 Benzoyl isothiocyanate 
• 57-13-6 urea 
• 540-72-7 sodium thiocyanide 

Downstream Products

• 23228-74-2 2-thiobiuret 
• 6291-91-4 N-(carbamoylcarbamoyl)benzamide 
• 69775-48-0 N-(3-oxo-2,3-dihydro-1,2,4-thiadiazol-5-yl)benzamide 
• 32622-40-5 6-phenyl-4-thioxo-3,4-dihydro-1,3,5-triazin-2(1H)-one 
• 7459-63-4 6-phenyl-1,3,5-triazine-2,4(1H,3H)-dione 
• 55-21-0 benzamide 

Relevant articles and documents

1,2,4-Thiadiazole acyclic nucleoside phosphonates as inhibitors of cysteine dependent enzymes cathepsin K and GSK-3β

In analogy to antiviral acyclic nucleoside phosphonates, a series of 5-amino-3-oxo-1,2,4-thiadiazol-3(2H)-ones bearing a 2-phosphonomethoxyethyl (PME) or 3-hydroxy-2-(phosphonomethoxy)propyl (HPMP) group at the position 2 of the heterocyclic moiety has be

Non-ATP competitive glycogen synthase kinase 3β (GSK-3β) inhibitors: Study of structural requirements for thiadiazolidinone derivatives

The 2,4-disubstituted thiadiazolidinones (TDZD) were described as the first non-ATP competitive GSK-3β inhibitors. New modifications in this heterocyclic ring are here reported to study the influence on the biological activity. The basic skeleton of 1,2,4-thiadiazole and also one of the carbonyl groups are kept, while different modifications are introduced in positions 3 and 5, respectively. The GSK-3β activity of the new thiadiazole derivatives here synthesized showed IC50 values for some of the compounds in the micromolar range. Additionally, ATP competition studies have been carried out, showing that as well as the first generation of TDZD, these new compounds act in a non-competitive manner. With this study, additional requirements for the biological activity of the TDZD family have been delineated.

Synthesis of 2-(2',3'-Dihydroxypropyl)-5-amino-2H-1,2,4-thiadiazol-3-one and 3-(2',3'-Dihydroxypropyl)-5-amino-3H-1,3,4-thiadiazol-2-one

The synthesis of two new acyclic nucleoside analogs, 2-(2',3'-dihydroxypropyl)-5-amino-2H-1,2,4-thiadiazol-3-one (1) and 3-(2',3'-dihydroxypropyl)-5-amino-3H-1,3,4-thiadiazol-2-one (2), is reported.The first compound, 1, was obtained by reaction of 3-chloro-1,2-propanediol with the sodium salt of 5-amino-2H-1,2,4-thiadiazol-3-one (3) in anhydrous dimethylformamide.Similarly, 5-amino-3H-1,3,4-thiadiazol-2-one (4) reacted with 3-chloro-1,2-propanediol to give 2.The thiadiazole 4 was prepared by condensation-cyclization of hydrazothiodicarbonamide (9).