7459-63-4

Basic information

• Product Name: 6-Phenyl-1,3,5-triazine-2,4-diol
• Synonyms: TRIAZINE-2,4-DIHYDROXY, 6-PHENYL-;2,4-DIHYDROXY-6-PHENYL-1,3,5-TRIAZINE;1,3,5-TRIAZINE-2,4-DIHYDROXY, 6-PHENYL-;6-Phenyl-1,3,5-triazine-2,4(1H,3H)-dione;6-phenyl-1,3,5-triazine-2,4-diol;6-PHENYL-TRIAZINE-2,4-DIHYDROXY
• CAS NO: 7459-63-4
• Molecular Formula: C₉H₇N₃O₂
• Molecular Weight: 189.17
• EINECS: 231-236-4
• Mol File: 7459-63-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 548.3 °C at 760 mmHg
• Flash Point: 285.4 °C
• Appearance: White Powder
• Density: 1.46 g/cm³
• Vapor Pressure: 1.24E-12mmHg at 25°C
• Refractive Index: 1.697
• CAS DataBase Reference: 6-Phenyl-1,3,5-triazine-2,4-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Phenyl-1,3,5-triazine-2,4-diol(7459-63-4)
• EPA Substance Registry System: 6-Phenyl-1,3,5-triazine-2,4-diol(7459-63-4)

Safety Data

• Hazardous Substances Data: 7459-63-4(Hazardous Substances Data)

Usage

General Description

6-Phenyl-1,3,5-triazine-2,4-diol, also known as PTAD, is a chemical compound with the molecular formula C9H7N3O2. It is a white to off-white crystalline powder that is soluble in organic solvents. PTAD is commonly used as a reagent in organic synthesis, particularly in the field of chemical analysis and the detection of various compounds. It is known for its ability to form stable complexes with certain organic compounds, making it useful in analytical techniques such as high-performance liquid chromatography (HPLC). PTAD also has potential applications in pharmaceuticals and materials science due to its unique chemical properties.

InChI:InChI=1/C9H7N3O2/c13-8-10-7(11-9(14)12-8)6-4-2-1-3-5-6/h1-5H,(H2,10,11,12,13,14)

Upstream product

• 1700-02-3 2,4-dichloro-6-phenyl-1,3,5-triazine 
• 6291-91-4 N-(carbamoylcarbamoyl)benzamide 
• 100-47-0 benzonitrile 
• 127099-85-8 N-Cyanoguanidine 
• 102-09-0 bis(phenyl) carbonate 
• 46187-84-2 N-(tert-butyl)benzimidamide 
• 1000668-98-3 phenyl (1-tert-butylamino-1-phenylmethylidene)carbamate 
• 93-58-3 benzoic acid methyl ester 
• 108-19-0 BIURET 
• 34277-78-6 N-(carbamoylcarbamothioyl)benzamide 
• 32622-40-5 6-phenyl-4-thioxo-3,4-dihydro-1,3,5-triazin-2(1H)-one 
• 99911-94-1 diphenyl iminodicarboxylate 

Downstream Products

• 1700-02-3 2,4-dichloro-6-phenyl-1,3,5-triazine 
• 30886-13-6 6-phenyl-1H-[1,3,5]triazine-2,4-dithione 
• 64398-66-9 bis-aziridin-1-yl-phenyl-[1,3,5]triazine 
• 62221-01-6 3,5-di(2-propenyl)-6-phenyl-1,3,5-triazine-2,4-dione 
• 88113-76-2 4-methoxy-1-methyl-6-phenyl-1H-[1,3,5]triazin-2-one 
• 62220-98-8 1,3-dimethyl-6-phenyl-1H-[1,3,5]triazine-2,4-dione 

Relevant articles and documents

Synthesis method of 2, 4-dihalogen-6-aryl substituted triazine derivative

The invention belongs to the technical field of compound synthesis, and particularly discloses a synthesis method of a 2, 4-dihalogen-6-aryl substituted triazine derivative. The synthesis method comprises the following steps: generating an intermediate triazine diketone compound from an aryl formate compound and biuret under the action of alkali, and reacting under the action of a halogenating reagent to obtain the 2, 4-dihalogen-6-aryl substituted triazine derivative. The method has the characteristics of cheap and accessible raw materials, can greatly lower the production cost, has the advantages of mild reaction conditions, single reaction product, fewer byproducts and no impurity removal difficulty, is simple in technological operation, can easily obtain the high-purity product, and issuitable for large-scale industrial production.

Synthesis and antivirus activity of 1,3,5-triazine derivatives

Reaction of 6-phenyl-4-thioxo-1,3,5-triazine-2-one with alkyl halide in the presence of 1 equiv. of sodium hydroxide resulted in 4-alkylthio-6-phenyl-1,3,5-triazine-2-one in good yield, whereas the above reaction provided 2-alkoxyl-4-alkylthio-6-phenyl-1,3,5-triazine in the presence of 2 equiv. of sodium hydroxide. 6-Phenyl-4-thioxo-1,3,5-triazine-2-one was oxidized with hydrogen peroxide to give 6-phenyl-1,3,5-triazine-2,4-dione. Further treatment with ethyl bromoacetate or (substituted) benzyl bromides yielded 2,4-dialkoxy-6-phenyl-1,3,5-triazines. At the same time, a small amount of 2-dimethylamino-4-alkoxy-6-phenyl-1,3,5-triazine were isolated. Preliminary bioassays indicate that the title compounds possess good activities against tobacco mosaic virus.