34280-99-4

Basic information

• Product Name: 3-(4-nitrophenyl)-2-phenylquinazolin-4(3H)-one
• Synonyms: 3-(4-nitrophenyl)-2-phenylquinazolin-4(3H)-one
• CAS NO: 34280-99-4
• Molecular Weight: 343.342
• Mol File: 34280-99-4.mol

Chemical Properties

• CAS DataBase Reference: 3-(4-nitrophenyl)-2-phenylquinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-nitrophenyl)-2-phenylquinazolin-4(3H)-one(34280-99-4)
• EPA Substance Registry System: 3-(4-nitrophenyl)-2-phenylquinazolin-4(3H)-one(34280-99-4)

Safety Data

• Hazardous Substances Data: 34280-99-4(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 3084-52-4 2-phenyl-4H-1,3-benzoxazin-4-one 
• 100-01-6 4-nitro-aniline 
• 1022-46-4 2-phenyl-4H-3,1-benzoxazin-4-one 

Downstream Products

• 76244-65-0 3-(4-aminophenyl)-2-phenylquinazolin-4(3H)-one 
• 133764-71-3 1-(4-Chloro-phenyl)-3-[4-(4-oxo-2-phenyl-4H-quinazolin-3-yl)-phenyl]-thiourea 

Relevant articles and documents

Copper-catalyzed consecutive reaction to construct quinazolin-4(3H)-ones and pyrido[2,3-d]pyrimidin-4(3H)-ones

An efficient and practical copper-catalyzed consecutive synthesis of quinazolin-4(3H)-ones and pyrido[2,3-d]pyrimidin-4(3H)-ones from easily available 2-halobenzamides (or 2-halonicotinamides), aldehydes, and sodium azide has been developed, which gave the corresponding target products in 50-95% yields for 29 examples. This remarkable consecutive process involved sequential copper-catalyzed SNAr, reduction, cyclization, and oxidation. Notably, this work would provide a novel synthetic strategy for bioactive molecules containing quinazolinone class skeletons.

Evaluation of antibacterial activity of novel quinazoline derivatives

In the present study, a series of novel quinazoline derivatives were synthesized by condensation with different aromatic amines via cyclized intermediate 2-phenyl-1,3-benzoxazin-4-one. The chemical structures were confirmed by means of IR and 1H NMR. These compounds were screened for antibacterial (Staphylococcus aureus ATCC-9144, Escherichia coli ATCC-25922, activities by paper disc diffusion technique. The potency of antibiotic content in samples can be determined by chemical, physical or biological means. An assay is made to determine the ability of an antibiotic to kill or inhibit the growth of living microorganism. The inhibition of microbial growth under standardized conditions may be utilized for demonstrating the therapeutic efficacy of drugs. Microorganism employed in biological assay are of various typesbacteria for amino acid, antibiotics, fungi for vitamins, trace elements, antibiotics and fungicidal and fungi static materials. The synthesized compounds were evaluated for antibacterial activity. Some of these synthesized compounds shown significant antibacterial activity.